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Dynamic Alu Methylation during Normal Development, Aging, and Tumorigenesis
Joint Authors
Luo, Yanting
Lu, Xuemei
Xie, Hehuang
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-27
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
DNA methylation primarily occurs on CpG dinucleotides and plays an important role in transcriptional regulations during tissue development and cell differentiation.
Over 25% of CpG dinucleotides in the human genome reside within Alu elements, the most abundant human repeats.
The methylation of Alu elements is an important mechanism to suppress Alu transcription and subsequent retrotransposition.
Decades of studies revealed that Alu methylation is highly dynamic during early development and aging.
Recently, many environmental factors were shown to have a great impact on Alu methylation.
In addition, aberrant Alu methylation has been documented to be an early event in many tumors and Alu methylation levels have been associated with tumor aggressiveness.
The assessment of the Alu methylation has become an important approach for early diagnosis and/or prognosis of cancer.
This review focuses on the dynamic Alu methylation during development, aging, and tumor genesis.
The cause and consequence of Alu methylation changes will be discussed.
American Psychological Association (APA)
Luo, Yanting& Lu, Xuemei& Xie, Hehuang. 2014. Dynamic Alu Methylation during Normal Development, Aging, and Tumorigenesis. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1016557
Modern Language Association (MLA)
Luo, Yanting…[et al.]. Dynamic Alu Methylation during Normal Development, Aging, and Tumorigenesis. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1016557
American Medical Association (AMA)
Luo, Yanting& Lu, Xuemei& Xie, Hehuang. Dynamic Alu Methylation during Normal Development, Aging, and Tumorigenesis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1016557
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016557