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Novel Study on N-Nitrosamines as Risk Factors of Cardiovascular Diseases
Joint Authors
Sheweita, Salah A.
El-Bendery, Heba A.
Mostafa, Mostafa H.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Millions of people are exposed daily to N-nitrosamines from different environmental sources.
The present study aims at investigating the role of N-nitrosamines in the alteration of homocysteine, lipid profile, oxidative stress, paraoxonase activity, antioxidant enzymes, and free radicals which are important risk factors for CVD.
In addition, biomarkers of cardiovascular diseases such as creatine kinase MB activity (CK-MB) and lactate dehydrogenase (LDH) as well as protein expression of both glutathione peroxidase and glutathione S-transferase π isozyme were assayed after treatment of rats with 0.2 mg/kg body weight of N-nitrosodibutylamine (NDBA), N-nitrosoethylbutylamine (NEBA), N-nitrosobutylpropylamine (NBPA), N-nitrosodiethylamine (NDEA), N-nitrosodimethylamine (NDMA), and N-nitrosodiphenylamine (NDPA) as a daily dose for two weeks.
LDL levels, paraoxonase activity, reduced glutathione levels, and glutathione reductase activities were increased, whereas HDL levels decreased after treatment of rats with most of N-nitrosamines compared to control group.
Moreover, levels of free radicals and catalase activity increased, whereas protein expression of both glutathione peroxidase and glutathione S-transferase decreased after treatment of rats with some N-nitrosamines.
The data showed that most N-nitrosamines increased CK-MB and LDH activities.
It is concluded that N-nitrosamines increased levels of free radicals, and decreased the activity of antioxidant enzymes which may consequently increase the incidence of CVDs.
American Psychological Association (APA)
Sheweita, Salah A.& El-Bendery, Heba A.& Mostafa, Mostafa H.. 2014. Novel Study on N-Nitrosamines as Risk Factors of Cardiovascular Diseases. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1016581
Modern Language Association (MLA)
Sheweita, Salah A.…[et al.]. Novel Study on N-Nitrosamines as Risk Factors of Cardiovascular Diseases. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1016581
American Medical Association (AMA)
Sheweita, Salah A.& El-Bendery, Heba A.& Mostafa, Mostafa H.. Novel Study on N-Nitrosamines as Risk Factors of Cardiovascular Diseases. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1016581
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016581