Acknowledged Signatures of Matrix Metalloproteinases in Takayasu’s Arteritis
Joint Authors
Wu, Gang
Mahajan, Nitin
Dhawan, Veena
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Takayasu’s arteritis (TA) was reported as an eye disease in the year 1905 and later was confirmed as a vasculitis.
Since then, the etiology of the disease remains unknown; however, characteristic clinical features suggest multiple causative factors.
Recent progress in vascular biology and other disciplines enlightens the pathophysiology of TA and demonstrated induction of various nonspecific inflammatory symptoms and destruction of the arterial wall, which leads to aneurysms and rupture of the affected arteries.
Matrix metalloproteinases (MMPs) as an enzyme family have well-established roles in several vascular pathologies including intima formation, atherosclerosiss and aneurysms.
MMPs have been proposed to be one of the molecules with a potential of having dual role in the course of TA, first as an active participant in pathophysiology and secondly as a diagnostic biomarker for TA disease.
The desire to improve our understanding of the importance of MMPs and their endogenous inhibitors (TIMPs) in TA disease and for the development of therapeutic agents has inspired basic and clinical scientists for over a decade.
In the present paper, we summarized the scientific rationale which highlights the signatures of matrix metalloproteinases and their endogenous inhibitors in pathophysiology as well as their being a potential candidate as biomarker for Takayasu’s arteritis.
American Psychological Association (APA)
Wu, Gang& Mahajan, Nitin& Dhawan, Veena. 2014. Acknowledged Signatures of Matrix Metalloproteinases in Takayasu’s Arteritis. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1016591
Modern Language Association (MLA)
Wu, Gang…[et al.]. Acknowledged Signatures of Matrix Metalloproteinases in Takayasu’s Arteritis. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1016591
American Medical Association (AMA)
Wu, Gang& Mahajan, Nitin& Dhawan, Veena. Acknowledged Signatures of Matrix Metalloproteinases in Takayasu’s Arteritis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1016591
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016591