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ECR-MAPK Regulation in Liver Early Development
Joint Authors
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Early growth is connected to a key link between embryonic development and aging.
In this paper, liver gene expression profiles were assayed at postnatal day 22 and week 16 of age.
Meanwhile another independent animal experiment and cell culture were carried out for validation.
Significance analysis of microarrays, qPCR verification, drug induction/inhibition assays, and metabonomics indicated that alpha-2u globulin (extracellular region)-socs2 (-SH2-containing signals/receptor tyrosine kinases)-ppp2r2a/pik3c3 (MAPK signaling)-hsd3b5/cav2 (metabolism/organization) plays a vital role in early development.
Taken together, early development of male rats is ECR and MAPK-mediated coordination of cancer-like growth and negative regulations.
Our data represent the first comprehensive description of early individual development, which could be a valuable basis for understanding the functioning of the gene interaction network of infant development.
American Psychological Association (APA)
Zhao, Xiu-Ju& Zhuo, Hexian. 2014. ECR-MAPK Regulation in Liver Early Development. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1016601
Modern Language Association (MLA)
Zhao, Xiu-Ju& Zhuo, Hexian. ECR-MAPK Regulation in Liver Early Development. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1016601
American Medical Association (AMA)
Zhao, Xiu-Ju& Zhuo, Hexian. ECR-MAPK Regulation in Liver Early Development. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1016601
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016601