Antimicrobial Peptides: Their Role as Infection-Selective Tracers for Molecular Imaging
Joint Authors
Ebenhan, Thomas
Gheysens, Olivier
Kruger, Hendrick Gert
Zeevaart, Jan Rijn
Sathekge, Mike Machaba
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-27
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Antimicrobial peptides (AMPs) are a heterogeneous class of compounds found in a variety of organisms including humans and, so far, hundreds of these structures have been isolated and characterised.
They can be described as natural microbicide, selectively cytotoxic to bacteria, whilst showing minimal cytotoxicity towards the mammalian cells of the host organism.
They act by their relatively strong electrostatic attraction to the negatively charged bacterial cells and a relatively weak interaction to the eukaryote host cells.
The ability of these peptides to accumulate at sites of infection combined with the minimal host’s cytotoxicity motivated for this review to highlight the role and the usefulness of AMPs for PET with emphasis on their mechanism of action and the different interactions with the bacterial cell.
These details are key information for their selective properties.
We also describe the strategy, design, and utilization of these peptides as potential radiopharmaceuticals as their combination with nuclear medicine modalities such as SPECT or PET would allow noninvasive whole-body examination for detection of occult infection causing, for example, fever of unknown origin.
American Psychological Association (APA)
Ebenhan, Thomas& Gheysens, Olivier& Kruger, Hendrick Gert& Zeevaart, Jan Rijn& Sathekge, Mike Machaba. 2014. Antimicrobial Peptides: Their Role as Infection-Selective Tracers for Molecular Imaging. BioMed Research International،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1016611
Modern Language Association (MLA)
Ebenhan, Thomas…[et al.]. Antimicrobial Peptides: Their Role as Infection-Selective Tracers for Molecular Imaging. BioMed Research International No. 2014 (2014), pp.1-15.
https://search.emarefa.net/detail/BIM-1016611
American Medical Association (AMA)
Ebenhan, Thomas& Gheysens, Olivier& Kruger, Hendrick Gert& Zeevaart, Jan Rijn& Sathekge, Mike Machaba. Antimicrobial Peptides: Their Role as Infection-Selective Tracers for Molecular Imaging. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1016611
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016611