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Identification of Endothelial Progenitor Cells in the Corpus Cavernosum in Rats
Joint Authors
Lee, Jun Sik
Hwang, In Sang
Lee, Hyun-Suk
Kim, Mi Eun
Seo, Young-Woo
Park, Kwangsung
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-20
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The vascular wall resident progenitor cells seem to serve as a local reservoir of cells for vascular repair.
It was hypothesized that the corpus cavernosum may contain vascular wall endothelial progenitor cells (EPCs).
In this study, we investigated the identification and localization of EPCs in the corpus cavernosum in a rat model.
Adult male Sprague-Dawley rats were used to isolate EPCs from corpora cavernosum.
To verify the existence and localization of EPCs, EPC-specific markers (CD34, Flk-1, and VE-cadherin) were evaluated by flow cytometric analysis and confocal microscopy.
The EPC markers were mainly expressed in the cavernosal sinusoidal endothelial space.
EPC-marker-positive cells made up about 3.31% of the corpus cavernosum of normal rat by FACS analysis.
As shown by confocal microscopy, CD34+/Flk-1+ and CD34+/VE-cadherin+ positive cells existed in the corpus cavernosum.
Our findings imply that regulation of corpus cavernosal EPCs may be a new therapeutic strategy in the treatment of erectile dysfunction.
American Psychological Association (APA)
Lee, Jun Sik& Hwang, In Sang& Lee, Hyun-Suk& Kim, Mi Eun& Seo, Young-Woo& Park, Kwangsung. 2014. Identification of Endothelial Progenitor Cells in the Corpus Cavernosum in Rats. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1016635
Modern Language Association (MLA)
Lee, Jun Sik…[et al.]. Identification of Endothelial Progenitor Cells in the Corpus Cavernosum in Rats. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1016635
American Medical Association (AMA)
Lee, Jun Sik& Hwang, In Sang& Lee, Hyun-Suk& Kim, Mi Eun& Seo, Young-Woo& Park, Kwangsung. Identification of Endothelial Progenitor Cells in the Corpus Cavernosum in Rats. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1016635
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016635