![](/images/graphics-bg.png)
Glatiramer Acetate and Nanny Proteins Restrict Access of the Multiple Sclerosis Autoantigen Myelin Basic Protein to the 26S Proteasome
Joint Authors
Kuzina, Ekaterina
Kudriaeva, Anna
Smirnov, Ivan
Dubina, Michael V.
Gabibov, Alexander
Belogurov, Alexey
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
We recently showed that myelin basic protein (MBP) is hydrolyzed by 26S proteasome without ubiquitination.
The previously suggested concept of charge-mediated interaction between MBP and the proteasome led us to attempt to compensate or mimic its positive charge to inhibit proteasomal degradation.
We demonstrated that negatively charged actin and calmodulin (CaM), as well as basic histone H1.3, inhibit MBP hydrolysis by competing with the proteasome and MBP, respectively, for binding their counterpart.
Interestingly, glatiramer acetate (GA), which is used to treat multiple sclerosis (MS) and is structurally similar to MBP, inhibits intracellular and in vitro proteasome-mediated MBP degradation.
Therefore, the data reported in this study may be important for myelin biogenesis in both the normal state and pathophysiological conditions.
American Psychological Association (APA)
Kuzina, Ekaterina& Kudriaeva, Anna& Smirnov, Ivan& Dubina, Michael V.& Gabibov, Alexander& Belogurov, Alexey. 2014. Glatiramer Acetate and Nanny Proteins Restrict Access of the Multiple Sclerosis Autoantigen Myelin Basic Protein to the 26S Proteasome. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1016644
Modern Language Association (MLA)
Kuzina, Ekaterina…[et al.]. Glatiramer Acetate and Nanny Proteins Restrict Access of the Multiple Sclerosis Autoantigen Myelin Basic Protein to the 26S Proteasome. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1016644
American Medical Association (AMA)
Kuzina, Ekaterina& Kudriaeva, Anna& Smirnov, Ivan& Dubina, Michael V.& Gabibov, Alexander& Belogurov, Alexey. Glatiramer Acetate and Nanny Proteins Restrict Access of the Multiple Sclerosis Autoantigen Myelin Basic Protein to the 26S Proteasome. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1016644
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016644