Multiple Analytical Approaches Demonstrate a Complex Relationship of Genetic and Nongenetic Factors with Cisplatin- and Carboplatin-Induced Nephrotoxicity in Lung Cancer Patients
Joint Authors
Liu, H. Eugene
Bai, Kuan-Jen
Hsieh, Yu-Chen
Yu, Ming-Chih
Lee, Chun-Nin
Chang, Jer-Hua
Hsu, Han-Lin
Lu, Pei-Chih
Chen, Hsiang-Yin
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Cisplatin and carboplatin cause nephrotoxicity by forming platinum-DNA adducts and lead to cell death.
Methods.
One-hundred and sixteen Taiwanese lung cancer patients who received cisplatin or carboplatin more than twice were recruited, and their genotypes were determined.
The risk of renal dysfunction, injury to the kidney, failure of kidney function, loss of kidney function, and end-stage kidney disease (RIFLE) criteria were used to evaluate the occurrence of nephrotoxicity.
A logistic regression, multiple regression with a classification and regression tree (CART), and the Framingham study risk score were used to analyze interactions between genetic and nongenetic factors in producing platinum-induced nephrotoxicity.
Results.
ERCC1 118C and TP53 72Arg polymorphisms were associated with increased risks of platinum-induced nephrotoxicity.
Other risk factors found included the platinum type, baseline serum creatinine (Scr), coadministration of vinorelbine, and the number of chemotherapy cycles.
The overall prediction rate of the CART was 82.7%, with a sensitivity of 0.630 and specificity of 0.896.
The Framingham study risk prediction model contained 7 factors.
Its prediction rate was 84.5%, with a sensitivity of 0.643 and specificity of 0.909.
Conclusions.
Genetic polymorphisms of ERCC1 and TP53 are risk factors for nephrotoxicity.
The CART analysis may provide a clinically applicable model to predict the risk of cisplatin- and carboplatin-induced nephrotoxicity.
American Psychological Association (APA)
Liu, H. Eugene& Bai, Kuan-Jen& Hsieh, Yu-Chen& Yu, Ming-Chih& Lee, Chun-Nin& Chang, Jer-Hua…[et al.]. 2014. Multiple Analytical Approaches Demonstrate a Complex Relationship of Genetic and Nongenetic Factors with Cisplatin- and Carboplatin-Induced Nephrotoxicity in Lung Cancer Patients. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1016653
Modern Language Association (MLA)
Liu, H. Eugene…[et al.]. Multiple Analytical Approaches Demonstrate a Complex Relationship of Genetic and Nongenetic Factors with Cisplatin- and Carboplatin-Induced Nephrotoxicity in Lung Cancer Patients. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1016653
American Medical Association (AMA)
Liu, H. Eugene& Bai, Kuan-Jen& Hsieh, Yu-Chen& Yu, Ming-Chih& Lee, Chun-Nin& Chang, Jer-Hua…[et al.]. Multiple Analytical Approaches Demonstrate a Complex Relationship of Genetic and Nongenetic Factors with Cisplatin- and Carboplatin-Induced Nephrotoxicity in Lung Cancer Patients. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1016653
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016653