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Effect of the Polydispersity of RBCs on the Recovery Rate of RBCs during the Removal of CPAs
Joint Authors
Qiao, Heyuan
Ding, Weiping
Ma, Yuncong
Sun, Sijie
Gao, Dayong
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-15
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
In the process of removing cryoprotectants from cryopreserved blood, the theoretically optimal operating condition, which is based on the assumption that the distribution of red blood cells is uniform, is often used to reduce or even avoid the hypotonic damage to cells.
However, due to the polydispersity of cells, the optimal condition is actually not reliable.
In this study, based on the discrete concept developed in our previous work, the effect of the polydispersity on the recovery rate of cells in the dilution-filtration system was statistically investigated by assigning three random parameters, isotonic cell volume, cell surface area, and osmotically inactive cell volume, to cells in small units of blood.
The results show that, due to the polydispersity, the real recovery rate deviates from the ideal value that is based on uniform distribution.
The deviation significantly increases with the standard errors of cell parameters, and it can be also magnified by high cryoprotectant concentrations.
Under the effect of polydispersity, the uniform distribution-based optimized blood or diluent flow rate is not perfect.
In practice, one should adopt a more conservative blood or diluent flow rate so that the hypotonic damage to cells can be further reduced.
American Psychological Association (APA)
Qiao, Heyuan& Ding, Weiping& Ma, Yuncong& Sun, Sijie& Gao, Dayong. 2014. Effect of the Polydispersity of RBCs on the Recovery Rate of RBCs during the Removal of CPAs. Computational and Mathematical Methods in Medicine،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1016833
Modern Language Association (MLA)
Qiao, Heyuan…[et al.]. Effect of the Polydispersity of RBCs on the Recovery Rate of RBCs during the Removal of CPAs. Computational and Mathematical Methods in Medicine No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1016833
American Medical Association (AMA)
Qiao, Heyuan& Ding, Weiping& Ma, Yuncong& Sun, Sijie& Gao, Dayong. Effect of the Polydispersity of RBCs on the Recovery Rate of RBCs during the Removal of CPAs. Computational and Mathematical Methods in Medicine. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1016833
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016833