Early Implementation of THAM for ICP Control: Therapeutic Hypothermia Avoidance and Reduction in HypertonicsHyperosmotics
Joint Authors
Zeiler, F. A.
Gillman, L. M.
Teitelbaum, J.
West, M.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-04
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Tromethamine (THAM) has been demonstrated to reduce intracranial pressure (ICP).
Early consideration for THAM may reduce the need for other measures for ICP control.
Objective.
To describe 4 cases of early THAM therapy for ICP control and highlight the potential to avoid TH and paralytics and achieve reduction in sedation and hypertonic/hyperosmotic agent requirements.
Methods.
We reviewed the charts of 4 patients treated with early THAM for ICP control.
Results.
We identified 2 patients with aneurysmal subarachnoid hemorrhage (SAH) and 2 with traumatic brain injury (TBI) receiving early THAM for ICP control.
The mean time to initiation of THAM therapy was 1.8 days, with a mean duration of 5.3 days.
In all patients, after 6 to 12 hours of THAM administration, ICP stability was achieved, with reduction in requirements for hypertonic saline and hyperosmotic agents.
There was a relative reduction in mean hourly hypertonic saline requirements of 89.1%, 96.1%, 82.4%, and 97.0% for cases 1, 2, 3, and 4, respectively, comparing pre- to post-THAM administration.
Mannitol, therapeutic hypothermia, and paralytics were avoided in all patients.
Conclusions.
Early administration of THAM for ICP control could potentially lead to the avoidance of other ICP directed therapies.
Prospective studies of early THAM administration are warranted.
American Psychological Association (APA)
Zeiler, F. A.& Gillman, L. M.& Teitelbaum, J.& West, M.. 2014. Early Implementation of THAM for ICP Control: Therapeutic Hypothermia Avoidance and Reduction in HypertonicsHyperosmotics. Case Reports in Critical Care،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-1016877
Modern Language Association (MLA)
Zeiler, F. A.…[et al.]. Early Implementation of THAM for ICP Control: Therapeutic Hypothermia Avoidance and Reduction in HypertonicsHyperosmotics. Case Reports in Critical Care No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-1016877
American Medical Association (AMA)
Zeiler, F. A.& Gillman, L. M.& Teitelbaum, J.& West, M.. Early Implementation of THAM for ICP Control: Therapeutic Hypothermia Avoidance and Reduction in HypertonicsHyperosmotics. Case Reports in Critical Care. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-1016877
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016877