Systemic Capillary Leak Syndrome: Is Methylene Blue the Silver Bullet?
Joint Authors
Umbrello, Michele
Gardinali, Marco
Ottolina, Davide
Zanforlin, Giancarlo
Iapichino, Gaetano
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Systemic capillary leak syndrome (SCLS) is a rare disorder characterized by unexplained, recurrent episodes of transient, abrupt increase in endothelial permeability, leading to severe hypotension, generalized edema, and hemoconcentration.
Case Report.
We report the case of a patient suffering from systemic capillary leak syndrome and present a possible interpretation of the pathophysiology of this condition.
Besides the classical triad of hypotension, edema, and hemoconcentration, we recorded increased levels of methemoglobin, an index of NO overproduction.
We present a possible interpretation of the pathophysiology of this condition based on the fast and complete reversal of symptoms after methylene blue administration (which opposes NO-induced effects) and speculate that increased NO levels could be implicated in the pathophysiology of the capillary leak phase.
Why should an emergency physician be aware of this? The safety of this treatment and its fluid- and cathecolamine-sparing effect deserve consideration and further research.
American Psychological Association (APA)
Umbrello, Michele& Gardinali, Marco& Ottolina, Davide& Zanforlin, Giancarlo& Iapichino, Gaetano. 2014. Systemic Capillary Leak Syndrome: Is Methylene Blue the Silver Bullet?. Case Reports in Critical Care،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1016878
Modern Language Association (MLA)
Umbrello, Michele…[et al.]. Systemic Capillary Leak Syndrome: Is Methylene Blue the Silver Bullet?. Case Reports in Critical Care No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1016878
American Medical Association (AMA)
Umbrello, Michele& Gardinali, Marco& Ottolina, Davide& Zanforlin, Giancarlo& Iapichino, Gaetano. Systemic Capillary Leak Syndrome: Is Methylene Blue the Silver Bullet?. Case Reports in Critical Care. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1016878
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016878