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Acute Methotrexate Toxicity: A Fatal Condition in Two Cases of Psoriasis
Joint Authors
Jariwala, Pankti
Kumar, Vinay
Kothari, Khyati
Thakkar, Sejal
Umrigar, Dipak Dayabhai
Source
Case Reports in Dermatological Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-08
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
We describe two fatal cases of low dose methotrexate (MTX) toxicity in patients with psoriasis, emphasizing the factors that exacerbate MTX toxicity.
The first patient was a 50-year-old male of psoriasis on intermittent treatment with MTX.
After a treatment-free period of six months, he had self-medication of MTX along with analgesic for joint pain for one week which followed ulceration of the lesions, bone marrow suppression, and eventually death.
The second patient was a 37-year-old male of psoriasis, who has taken MTX one week earlier without prior investigations.
He had painful ulcerated skin lesions and bone marrow suppression.
On investigations, he showed high creatinine level and atrophied, nonfunctioning right kidney on ultrasonography.
In spite of dialysis, he succumbed to death.
MTX is safe and effective if monitored properly, but inadvertent use may lead to even death also.
Prior workup and proper counseling regarding the drug interactions as well as self-medication should be enforced.
American Psychological Association (APA)
Jariwala, Pankti& Kumar, Vinay& Kothari, Khyati& Thakkar, Sejal& Umrigar, Dipak Dayabhai. 2014. Acute Methotrexate Toxicity: A Fatal Condition in Two Cases of Psoriasis. Case Reports in Dermatological Medicine،Vol. 2014, no. 2014, pp.1-3.
https://search.emarefa.net/detail/BIM-1016988
Modern Language Association (MLA)
Jariwala, Pankti…[et al.]. Acute Methotrexate Toxicity: A Fatal Condition in Two Cases of Psoriasis. Case Reports in Dermatological Medicine No. 2014 (2014), pp.1-3.
https://search.emarefa.net/detail/BIM-1016988
American Medical Association (AMA)
Jariwala, Pankti& Kumar, Vinay& Kothari, Khyati& Thakkar, Sejal& Umrigar, Dipak Dayabhai. Acute Methotrexate Toxicity: A Fatal Condition in Two Cases of Psoriasis. Case Reports in Dermatological Medicine. 2014. Vol. 2014, no. 2014, pp.1-3.
https://search.emarefa.net/detail/BIM-1016988
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016988