Neoadjuvant Concurrent Chemoradiation for Curative Treatment of Penile Squamous Cell Carcinoma
Joint Authors
Chhabra, Arpit
Schwartz, David
Leaf, Andrea
Karanikolas, Nikolaos
Weiss, Jeffrey P.
Schreiber, David
Source
Case Reports in Oncological Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-07
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Penile cancer is a rare malignancy often treated with neoadjuvant chemotherapy followed by surgery.
However, the utility of neoadjuvant chemoradiation, particularly when the tumor is resistant to chemotherapy alone, has not been established.
In this study, we report a case of pT3cN3M0 penile squamous cell carcinoma with progression of nodal disease on chemotherapy, which was cured with use of neoadjuvant concurrent chemoradiation.
Case Report.
A 65-year-old male presented with a fixed left inguinal lymph node with associated firmness of the penile glans.
Biopsies of both sites revealed evidence of squamous cell carcinoma.
The patient underwent partial penectomy for the primary lesion and began neoadjuvant chemotherapy to reduce the size of the unresectable left inguinal node.
However, he displayed disease progression in the left inguinal node.
As such, we attempted concurrent chemoradiation therapy with regression of his nodal disease.
The patient was able to undergo left inguinal node dissection and has no evidence of disease 18 months since his initial surgery.
Conclusion.
The use of neoadjuvant chemoradiation for bulky cN2-3 disease seems appropriate in the setting of progressive disease.
Further studies are necessary to assess the utility of concurrent chemoradiation both in the neoadjuvant and salvage setting.
American Psychological Association (APA)
Chhabra, Arpit& Schwartz, David& Leaf, Andrea& Karanikolas, Nikolaos& Weiss, Jeffrey P.& Schreiber, David. 2014. Neoadjuvant Concurrent Chemoradiation for Curative Treatment of Penile Squamous Cell Carcinoma. Case Reports in Oncological Medicine،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-1017384
Modern Language Association (MLA)
Chhabra, Arpit…[et al.]. Neoadjuvant Concurrent Chemoradiation for Curative Treatment of Penile Squamous Cell Carcinoma. Case Reports in Oncological Medicine No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-1017384
American Medical Association (AMA)
Chhabra, Arpit& Schwartz, David& Leaf, Andrea& Karanikolas, Nikolaos& Weiss, Jeffrey P.& Schreiber, David. Neoadjuvant Concurrent Chemoradiation for Curative Treatment of Penile Squamous Cell Carcinoma. Case Reports in Oncological Medicine. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-1017384
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1017384