![](/images/graphics-bg.png)
Axillary Metaplastic Breast Carcinoma with Ipsilateral Pectoral Invasive Ductal Carcinoma: An Unusual Presentation
Joint Authors
Zhang, Lei
Comertpay, Sabahattin
Shimizu, David
DeMay, Richard M.
Carbone, Michele
Honda, Stacey A.
Eaves, Jodi M. Matsuura
Source
Case Reports in Oncological Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
We report a case of axillary metaplastic breast carcinoma (MBC) with triple negative (ER−/PR−/Her2−) phenotype, concurrent with multifocal invasive ductal carcinoma (IDC) of ipsilateral pectoral breast (ER+/PR+/Her2−) in a 60-year-old woman.
The two tumors demonstrate different morphology, immunophenotype, and opposite response to neoadjuvant chemotherapy of paclitaxol, adriamycin, and cyclophosphamide.
Methylation analysis of human androgen receptor (HUMARA) on X-chromosome identified monoclonal pattern of X-chromosome inactivation in MBC and mosaic pattern in the IDC.
Stem cell origin of MBC is suggested in this case.
Clinicopathological features, imaging findings, biological markers, chemoradiation management, and prognosis of MBC are reviewed in comparison to invasive ductal carcinoma.
Our case and literature review suggest that traditional chemotherapy applicable to IDC is less effective towards MBC.
However, new chemotherapy protocols targeting stem cell and multimodality management of MBC are promising.
Recognition of unusual presentation of MBC will help tailor therapy towards tumor with worse prognosis.
American Psychological Association (APA)
Zhang, Lei& Comertpay, Sabahattin& Shimizu, David& DeMay, Richard M.& Carbone, Michele& Honda, Stacey A.…[et al.]. 2014. Axillary Metaplastic Breast Carcinoma with Ipsilateral Pectoral Invasive Ductal Carcinoma: An Unusual Presentation. Case Reports in Oncological Medicine،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1017397
Modern Language Association (MLA)
Zhang, Lei…[et al.]. Axillary Metaplastic Breast Carcinoma with Ipsilateral Pectoral Invasive Ductal Carcinoma: An Unusual Presentation. Case Reports in Oncological Medicine No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1017397
American Medical Association (AMA)
Zhang, Lei& Comertpay, Sabahattin& Shimizu, David& DeMay, Richard M.& Carbone, Michele& Honda, Stacey A.…[et al.]. Axillary Metaplastic Breast Carcinoma with Ipsilateral Pectoral Invasive Ductal Carcinoma: An Unusual Presentation. Case Reports in Oncological Medicine. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1017397
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1017397