Scleritis Caused by In Vitro Linezolid-Resistant Nocardia asteroides
Joint Authors
Gonzalez, Andres
Fakhar, Kaihan
Gubernick, David
Tuli, Sonal
Source
Case Reports in Ophthalmological Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-23
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Purpose.
To describe a case of postoperative scleritis caused by a novel strain of Nocardia resistant to linezolid and trimethoprim-sulfamethoxazole (TMP-SMX).
Methods.
Case report of a patient with microbiologically proven scleritis due to Nocardia asteroides.
Results.
The patient presented with pain, redness, and nodules on the sclera three months following pterygium excision with mitomycin C and amniotic membrane placement.
As no response was noted with empiric treatment for bacterial scleritis, debridement was performed.
The cytopathology report showed gram positive filamentous bacteria.
A presumptive diagnosis of Nocardia scleritis was made and therapy was initiated based on a literature review on treatments for Nocardia infections.
Cultures returned growing Nocardia asteroides.
Antibiotic sensitivity testing revealed resistance to linezolid and TMP-SMX which are the traditional drugs of choice for Nocardia.
The patient was treated with amikacin and imipenem as well as extensive debridement with pedicle grafts.
The patient’s scleritis resolved with a good visual outcome.
Conclusions.
Cultures should be obtained in all cases of necrotizing scleritis in patients with a recent history of conjunctival surgery to rule out unusual organisms such as Nocardia.
Although literature states that resistance to linezolid and TMP-SMX is rare in Nocardia, sensitivity testing can be useful in unresponsive cases.
American Psychological Association (APA)
Gonzalez, Andres& Fakhar, Kaihan& Gubernick, David& Tuli, Sonal. 2014. Scleritis Caused by In Vitro Linezolid-Resistant Nocardia asteroides. Case Reports in Ophthalmological Medicine،Vol. 2014, no. 2014, pp.1-3.
https://search.emarefa.net/detail/BIM-1017412
Modern Language Association (MLA)
Gonzalez, Andres…[et al.]. Scleritis Caused by In Vitro Linezolid-Resistant Nocardia asteroides. Case Reports in Ophthalmological Medicine No. 2014 (2014), pp.1-3.
https://search.emarefa.net/detail/BIM-1017412
American Medical Association (AMA)
Gonzalez, Andres& Fakhar, Kaihan& Gubernick, David& Tuli, Sonal. Scleritis Caused by In Vitro Linezolid-Resistant Nocardia asteroides. Case Reports in Ophthalmological Medicine. 2014. Vol. 2014, no. 2014, pp.1-3.
https://search.emarefa.net/detail/BIM-1017412
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1017412