Top Differential Diagnosis Should Be Microscopic Polyangiitis in ANCA-Positive Patient with Diffuse Pulmonary Hemorrhage and Hemosiderosis
Joint Authors
Ward, Nicholas D.
Cosner, Diane E.
Lamb, Colleen A.
Li, Wei
Macknis, Jacqueline K.
Rooney, Michele T.
Zhang, Ping L.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-27
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
A rat model of antineutrophil cytoplasmic antibody (ANCA) associated vasculitides reveals crescentic glomerulonephritis as seen in human renal biopsies and diffuse lung hemorrhage that is not well documented in human lung biopsies.
A 64-year-old male, with shortness of breath and mild elevation of serum creatinine, was found to have a positive serum test for ANCA, but negative antiglomerular basement membrane antibody.
A renal biopsy showed pauci-immune type of crescentic glomerulonephritis and focal arteritis.
The prior lung wedge biopsy was retrospectively reviewed to show diffuse hemorrhage and hemosiderosis with focal giant cells.
In addition, small arteries revealed subtle neutrophil aggregation, and margination along vascular endothelium, but no definitive vasculitis.
The pathology of ANCA associated vasculitides results from activated neutrophils by ANCA and subsequent activation of the alternative complement cascade with endothelial injury, neutrophil aggregation and margination.
Our findings, after the correlation between lung biopsy and renal biopsy, imply that the top differential diagnosis in the lung biopsy should be microscopic polyangiitis when diffuse pulmonary hemorrhage and hemosiderosis are present in this ANCA-positive patient.
American Psychological Association (APA)
Ward, Nicholas D.& Cosner, Diane E.& Lamb, Colleen A.& Li, Wei& Macknis, Jacqueline K.& Rooney, Michele T.…[et al.]. 2014. Top Differential Diagnosis Should Be Microscopic Polyangiitis in ANCA-Positive Patient with Diffuse Pulmonary Hemorrhage and Hemosiderosis. Case Reports in Pathology،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1017524
Modern Language Association (MLA)
Ward, Nicholas D.…[et al.]. Top Differential Diagnosis Should Be Microscopic Polyangiitis in ANCA-Positive Patient with Diffuse Pulmonary Hemorrhage and Hemosiderosis. Case Reports in Pathology No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1017524
American Medical Association (AMA)
Ward, Nicholas D.& Cosner, Diane E.& Lamb, Colleen A.& Li, Wei& Macknis, Jacqueline K.& Rooney, Michele T.…[et al.]. Top Differential Diagnosis Should Be Microscopic Polyangiitis in ANCA-Positive Patient with Diffuse Pulmonary Hemorrhage and Hemosiderosis. Case Reports in Pathology. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1017524
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1017524