Serum Clusterin as a Tumor Marker and Prognostic Factor for Patients with Esophageal Cancer
Joint Authors
Guo, Wei
Ma, Xiao
Xue, Christine
Luo, Jianfeng
Zhu, Xiaoli
Xiang, Jiaqing
Lu, Bo
Li, Hecheng
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Recent studies have revealed that clusterin is implicated in many physiological and pathological processes, including tumorigenesis.
However, the relationship between serum clusterin expression and esophageal squamous cell carcinoma (ESCC) is unclear.
Methods.
The serum clusterin concentrations of 87 ESCC patients and 136 healthy individuals were examined.
An independent-samples Mann-Whitney U test was used to compare serum clusterin concentrations of ESCC patients to those of healthy controls.
Univariate analysis was conducted using the log-rank test and multivariate analyses were performed using the Cox proportional hazards model.
Results.
In healthy controls, the mean clusterin concentration was 288.8 ± 75.1 μg/mL, while in the ESCC patients, the mean clusterin concentration was higher at 412.3 ± 159.4 μg/mL ( P < 0.0001 ).
The 1-, 2-, and 4-year survival rates for the 87 ESCC patients were 89.70%, 80.00%, and 54.50%.
Serum clusterin had an optimal diagnostic cut-off point (serum clusterin concentration = 335.5 μg/mL) for esophageal squamous cell carcinoma with sensitivity of 71.26% and specificity of 77.94%.
And higher serum clusterin concentration (>500 μg/mL) indicated better prognosis ( P = 0.030 ).
Conclusions.
Clusterin may play a key role during tumorigenesis and tumor progression of ESCC and it could be applied in clinical work as a tumor marker and prognostic factor.
American Psychological Association (APA)
Guo, Wei& Ma, Xiao& Xue, Christine& Luo, Jianfeng& Zhu, Xiaoli& Xiang, Jiaqing…[et al.]. 2014. Serum Clusterin as a Tumor Marker and Prognostic Factor for Patients with Esophageal Cancer. Disease Markers،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1017984
Modern Language Association (MLA)
Guo, Wei…[et al.]. Serum Clusterin as a Tumor Marker and Prognostic Factor for Patients with Esophageal Cancer. Disease Markers No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1017984
American Medical Association (AMA)
Guo, Wei& Ma, Xiao& Xue, Christine& Luo, Jianfeng& Zhu, Xiaoli& Xiang, Jiaqing…[et al.]. Serum Clusterin as a Tumor Marker and Prognostic Factor for Patients with Esophageal Cancer. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1017984
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1017984