MicroRNA Expression Profiling in PBMCs: A Potential Diagnostic Biomarker of Chronic Hepatitis C
Joint Authors
Chang, Chiu-Chun
Lin, Chun-Che
Hsieh, Wan-Ling
Lai, Hsin-Wu
Tsai, Chia-Hsun
Cheng, Ya-Wen
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The expression levels of miR-16, miR-193b, miR-199a, miR-222, and miR-324 in PBMCs were significantly higher in CHC patients compared with healthy controls and significantly different between CHC patients with HCV genotype 1 (GT-1) and non-genotype-1 (non-GT-1).
Multivariate logistic regression analysis also showed that patients with high expression levels of the six target miRNAs had an approximately 7.202-fold risk of CHC compared with those with low expression levels of the target miRNAs.
We concluded that the expression levels of miR-16, miR-193b, miR-199a, miR-222, and miR-324 target miRNAs in PBMCs of CHC may act as significant risk biomarkers for the development of CHC.
American Psychological Association (APA)
Chang, Chiu-Chun& Lin, Chun-Che& Hsieh, Wan-Ling& Lai, Hsin-Wu& Tsai, Chia-Hsun& Cheng, Ya-Wen. 2014. MicroRNA Expression Profiling in PBMCs: A Potential Diagnostic Biomarker of Chronic Hepatitis C. Disease Markers،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1018002
Modern Language Association (MLA)
Chang, Chiu-Chun…[et al.]. MicroRNA Expression Profiling in PBMCs: A Potential Diagnostic Biomarker of Chronic Hepatitis C. Disease Markers No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1018002
American Medical Association (AMA)
Chang, Chiu-Chun& Lin, Chun-Che& Hsieh, Wan-Ling& Lai, Hsin-Wu& Tsai, Chia-Hsun& Cheng, Ya-Wen. MicroRNA Expression Profiling in PBMCs: A Potential Diagnostic Biomarker of Chronic Hepatitis C. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1018002
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018002