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Mig-6 Gene Knockout Induces Neointimal Hyperplasia in the Vascular Smooth Muscle Cell
Joint Authors
Lee, Ju Hee
Choung, Sorim
Kim, Ji Min
Lee, Jung Uee
Kim, Koon Soon
Kim, Hyun Jin
Jeong, Jae-Wook
Ku, Bon Jeong
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Although advances in vascular interventions can reduce the mortality associated with cardiovascular disease, neointimal hyperplasia remains a clinically significant obstacle limiting the success of current interventions.
Identification of signaling pathways involved in migration and proliferation of vascular smooth muscle cells (SMCs) is an important approach for the development of modalities to combat this disease.
Herein we investigate the role of an immediate early response gene, mitogen-inducible gene-6 (Mig-6), in the development of neointimal hyperplasia using vascular smooth muscle specific Mig-6 knockout mice.
We induced endoluminal injury to one side of femoral artery by balloon dilatation in both Mig-6 knockout and control mice.
Four weeks following injury, the artery of Mig-6 knockout mice demonstrated a 5.3-fold increase in the neointima/media ratio compared with control mice ( P = 0.04 ) .
In addition, Mig-6 knockout vascular SMCs displayed an increase in both cell migration and proliferation compared with wild-type SMCs.
Taken together, our data suggest that Mig-6 plays a critical role in the development of atherosclerosis.
This finding provides new insight into the development of more effective ways to treat and prevent neointimal hyperplasia, particularly in-stent restenosis after percutaneous vascular intervention.
American Psychological Association (APA)
Lee, Ju Hee& Choung, Sorim& Kim, Ji Min& Lee, Jung Uee& Kim, Koon Soon& Kim, Hyun Jin…[et al.]. 2014. Mig-6 Gene Knockout Induces Neointimal Hyperplasia in the Vascular Smooth Muscle Cell. Disease Markers،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1018017
Modern Language Association (MLA)
Lee, Ju Hee…[et al.]. Mig-6 Gene Knockout Induces Neointimal Hyperplasia in the Vascular Smooth Muscle Cell. Disease Markers No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1018017
American Medical Association (AMA)
Lee, Ju Hee& Choung, Sorim& Kim, Ji Min& Lee, Jung Uee& Kim, Koon Soon& Kim, Hyun Jin…[et al.]. Mig-6 Gene Knockout Induces Neointimal Hyperplasia in the Vascular Smooth Muscle Cell. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1018017
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018017