Prognostic Significance of MicroRNA-375 Downregulation in Solid Tumors: A Meta-Analysis
Joint Authors
Shao, Yingjie
Geng, Yiting
Gu, Wendong
Huang, Jin
Ning, Zhonghua
Pei, Honglei
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Recently, many studies have shown that microRNAs (miRNA) exhibit altered expression in various cancers and may play an important role as prognostic biomarker of cancers.
We performed a meta-analysis to evaluate the impact of miR-375 expression in solid tumors on patients’ overall survival (OS).
Methods.
Studies were identified by searching PubMed, Embace, and Cochrane Library (last search update was in May 2014) and were assessed by further quality evaluation.
The pooled hazard ratios (HRs) with 95% confidence intervals (CIs) for total and stratified analyses were calculated to investigate the association between miR-375 expression and cancer patients OS.
Results.
Our analysis results indicated that downregulation of miR-375 predicted poor OS (HR = 1.91, 95% CI 1.48–2.45, P<0.001).
Subgroup analyses showed that lower expression of miR-375 was significantly related with poor OS in patients with esophageal carcinoma (HR = 2.24, 95% CI 1.69–2.96, P<0.001) and non-small-cell lung cancer (NSCLC) (HR = 1.71, 95% CI 1.31–2.24, P<0.001).
Conclusions.
The findings from this meta-analysis suggest that miR-375 expression is associated with OS of patients with malignant tumors and could be a useful clinical prognostic biomarker.
American Psychological Association (APA)
Shao, Yingjie& Geng, Yiting& Gu, Wendong& Huang, Jin& Ning, Zhonghua& Pei, Honglei. 2014. Prognostic Significance of MicroRNA-375 Downregulation in Solid Tumors: A Meta-Analysis. Disease Markers،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1018022
Modern Language Association (MLA)
Shao, Yingjie…[et al.]. Prognostic Significance of MicroRNA-375 Downregulation in Solid Tumors: A Meta-Analysis. Disease Markers No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1018022
American Medical Association (AMA)
Shao, Yingjie& Geng, Yiting& Gu, Wendong& Huang, Jin& Ning, Zhonghua& Pei, Honglei. Prognostic Significance of MicroRNA-375 Downregulation in Solid Tumors: A Meta-Analysis. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1018022
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018022