ZEB1 Expression in Endometrial Biopsy Predicts Lymph Node Metastases in Patient with Endometrial Cancer
Joint Authors
Feng, Gang
Wang, Xiangming
Cao, Xiaozhi
Shen, Lijuan
Zhu, Jiansheng
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Purpose.
The purpose of this study was to analyze the expression of zinc-finger E-box-binding homeobox 1 (ZEB1) in endometrial biopsy and its correlation with preoperative characteristics, including lymph node metastases in patient with endometrial cancer.
Methods.
Using quantitative RT-PCR, ZEB1 expressions in endometrial biopsy from 452 patients were measured.
The relationship between ZEB1 expression and preoperative characteristics was analyzed.
Results.
ZEB1 expressions were significantly associated with subtype, grade, myometrial invasion, and lymph node metastases.
Lymph node metastases could be identified with a sensitivity of 57.8% at specificity of 74.1% by ZEB1 expression in endometrial biopsy.
Based on combination of preoperative characteristics and ZEB1 expression, lymph node metastases could be identified with a sensitivity of 62.1% at specificity of 96.2% prior to hysterectomy.
Conclusion.
ZEB1 expression in endometrial biopsy could help physicians to better predict the lymph node metastasis in patients with endometrial cancer prior to hysterectomy.
American Psychological Association (APA)
Feng, Gang& Wang, Xiangming& Cao, Xiaozhi& Shen, Lijuan& Zhu, Jiansheng. 2014. ZEB1 Expression in Endometrial Biopsy Predicts Lymph Node Metastases in Patient with Endometrial Cancer. Disease Markers،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1018024
Modern Language Association (MLA)
Feng, Gang…[et al.]. ZEB1 Expression in Endometrial Biopsy Predicts Lymph Node Metastases in Patient with Endometrial Cancer. Disease Markers No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1018024
American Medical Association (AMA)
Feng, Gang& Wang, Xiangming& Cao, Xiaozhi& Shen, Lijuan& Zhu, Jiansheng. ZEB1 Expression in Endometrial Biopsy Predicts Lymph Node Metastases in Patient with Endometrial Cancer. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1018024
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018024