A Disease Modification Effect of APOE E4 on the Association between Urinary Albumin Excretion and Cognition in Korean Adults
Joint Authors
Shin, Min-Ho
Kweon, Sun-Seog
Choi, Jin-Su
Lee, Young-Hoon
Nam, Hae-Sung
Park, Kyeong-Soo
Kim, Hee Nam
Oh, Sun-Young
Jeong, Seul-Ki
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
No previous study examined a disease modifying effect of APOE E4 status on the association between the urinary albumin-to-creatinine ratio (UACR) and cognition.
This study aimed to investigate whether APOE E4 modified the association in Korean adults.
Methods.
We performed a cross-sectional study in adults aged 45 to 74 who were living in Namwon City, Republic of Korea.
Cognitive function was measured with the Korean version of modified Mini-Mental State Examination (K-mMMSE) and cognitive impairment was defined as scores falling below the 25th percentile of the K-mMMSE according to age, sex, and educational attainments.
Results.
A total of 10,190 participants (4006 men and 6184 women) were analyzed in the present study.
Of these, 1698 subjects (16.7%) were APOE E4 carriers.
The UACR values were negatively associated with the K-mMMSE scores, even after adjusting for potential confounders including age, sex, education, and vascular risk factors.
APOE E4 modified the association significantly, resulting in a steeper decline of cognitive function with the increase in UACR in E4 carriers (P for interaction = 0.021).
Conclusion.
Higher UACR values were significantly associated with cognitive dysfunction in the general Korean population, with cognition in APOE E4 carriers being more severely affected by increased UACR.
American Psychological Association (APA)
Shin, Min-Ho& Kweon, Sun-Seog& Choi, Jin-Su& Lee, Young-Hoon& Nam, Hae-Sung& Park, Kyeong-Soo…[et al.]. 2014. A Disease Modification Effect of APOE E4 on the Association between Urinary Albumin Excretion and Cognition in Korean Adults. Disease Markers،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1018025
Modern Language Association (MLA)
Shin, Min-Ho…[et al.]. A Disease Modification Effect of APOE E4 on the Association between Urinary Albumin Excretion and Cognition in Korean Adults. Disease Markers No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1018025
American Medical Association (AMA)
Shin, Min-Ho& Kweon, Sun-Seog& Choi, Jin-Su& Lee, Young-Hoon& Nam, Hae-Sung& Park, Kyeong-Soo…[et al.]. A Disease Modification Effect of APOE E4 on the Association between Urinary Albumin Excretion and Cognition in Korean Adults. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1018025
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018025