A Comparison of KL-6 and Clara Cell Protein as Markers for Predicting Bronchopulmonary Dysplasia in Preterm Infants
Joint Authors
Wang, Keyi
Huang, Xianmei
Lu, Hui
Zhang, Zhiqun
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
|Objectives.
To evaluate the predictive characteristics of KL-6 and CC16 for bronchopulmonary dysplasia (BPD) in preterm infants, either independently or in combination.
Study Design.
This prospective cohort study was performed from 2011 to 2013 with preterm neonates of gestational age ≤32 weeks and birth weight ≤1500 g.
Serum KL-6 and CC16 levels were determined 7 and 14 days after birth.
Results.
Seventy-three preterm infants were studied.
BPD was identified in 24 of these infants.
After adjusting for potential confounders, serum KL-6 concentrations were found to be elevated in BPD infants at both time points relative to non-BPD infants, while serum CC16 concentrations were lower at 14 days.
At both 7 d and 14 d of life the predictive power of KL-6 levels exceeded that of CC16 (area under receiver operating characteristic curve: at 7 d, 0.91 cf.
0.73, P=0.02; at 14 d, 0.95 cf.
0.85, P=0.05).
The combination of these markers enhanced the sensitivity further.
Conclusions.
Serum KL-6 levels higher than 79.26 ng/mL at 14 days postpartum in preterm infants predict the occurrence of BPD.
CC16 was less predictive than KL-6 at this time point, but KL-6 and CC16 together enhanced the prediction.
American Psychological Association (APA)
Wang, Keyi& Huang, Xianmei& Lu, Hui& Zhang, Zhiqun. 2014. A Comparison of KL-6 and Clara Cell Protein as Markers for Predicting Bronchopulmonary Dysplasia in Preterm Infants. Disease Markers،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1018026
Modern Language Association (MLA)
Wang, Keyi…[et al.]. A Comparison of KL-6 and Clara Cell Protein as Markers for Predicting Bronchopulmonary Dysplasia in Preterm Infants. Disease Markers No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1018026
American Medical Association (AMA)
Wang, Keyi& Huang, Xianmei& Lu, Hui& Zhang, Zhiqun. A Comparison of KL-6 and Clara Cell Protein as Markers for Predicting Bronchopulmonary Dysplasia in Preterm Infants. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1018026
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018026