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The Use of Humoral Responses as a Marker of CMV Burden in HIV Patients on ART Requires Consideration of T-Cell Recovery and Persistent B-Cell Activation
Joint Authors
Brunt, Samantha J.
Lee, Silvia
D’Orsogna, Lloyd
Bundell, Christine
Burrows, Sally
Price, P.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
|Objectives.
Elevated humoral responses to cytomegalovirus (CMV) associate with increased risk of cardiovascular disease (CVD) in HIV patients on antiretroviral therapy (ART).
To better understand the persistence of CMV humoral responses in relation to CVD, we determined trends in CMV antibody levels over the first 10 years on ART.
Design.
We describe longitudinal analyses of plasma from 13 HIV patients commencing ART with <210 CD4 T-cells/µL and 27 controls.
Antibodies reactive with CMV (fibroblast lysate, gB and IE-1 antigens), EBV-VCA, and HIVgp41 were quantitated.
B-cell activation was assessed via total IgG and sBAFF.
Inflammation was assessed via sTNF-RI and sCD14.
Results.
Amongst CMV seropositive HIV patients, levels of antibody reactive with CMV (P=0.03) and EBV-VCA (P=0.02) peaked after 1 year on ART.
Levels of total IgG, sCD14, and sTNF-RI declined to approximate those in controls after 10 years, but sBAFF (P=0.0002), EBV-VCA (P=0.001), and CMV (P=0.0004) antibodies remained elevated.
A strong correlation between sBAFF and CMVgB antibody was seen at 10 years (R=0.93, P=0.0009) and verified in a second cohort.
Conclusions.
CMV antibody titres peak on ART and remain high.
A correlation between CMV antibody and sBAFF suggests a role for HIV-induced B-cell pathology that may affect its use as a marker of CMV burden.
American Psychological Association (APA)
Brunt, Samantha J.& Lee, Silvia& D’Orsogna, Lloyd& Bundell, Christine& Burrows, Sally& Price, P.. 2014. The Use of Humoral Responses as a Marker of CMV Burden in HIV Patients on ART Requires Consideration of T-Cell Recovery and Persistent B-Cell Activation. Disease Markers،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1018038
Modern Language Association (MLA)
Brunt, Samantha J.…[et al.]. The Use of Humoral Responses as a Marker of CMV Burden in HIV Patients on ART Requires Consideration of T-Cell Recovery and Persistent B-Cell Activation. Disease Markers No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1018038
American Medical Association (AMA)
Brunt, Samantha J.& Lee, Silvia& D’Orsogna, Lloyd& Bundell, Christine& Burrows, Sally& Price, P.. The Use of Humoral Responses as a Marker of CMV Burden in HIV Patients on ART Requires Consideration of T-Cell Recovery and Persistent B-Cell Activation. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1018038
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018038