Sporotrichosis: An Overview and Therapeutic Options

Author

Mahajan, Vikram K.

Source

Dermatology Research and Practice

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-12-28

Country of Publication

Egypt

No. of Pages

13

Main Subjects

Diseases

Abstract EN

Sporotrichosis is a chronic granulomatous mycotic infection caused by Sporothrix schenckii, a common saprophyte of soil, decaying wood, hay, and sphagnum moss, that is endemic in tropical/subtropical areas.

The recent phylogenetic studies have delineated the geographic distribution of multiple distinct Sporothrix species causing sporotrichosis.

It characteristically involves the skin and subcutaneous tissue following traumatic inoculation of the pathogen.

After a variable incubation period, progressively enlarging papulo-nodule at the inoculation site develops that may ulcerate (fixed cutaneous sporotrichosis) or multiple nodules appear proximally along lymphatics (lymphocutaneous sporotrichosis).

Osteoarticular sporotrichosis or primary pulmonary sporotrichosis are rare and occur from direct inoculation or inhalation of conidia, respectively.

Disseminated cutaneous sporotrichosis or involvement of multiple visceral organs, particularly the central nervous system, occurs most commonly in persons with immunosuppression.

Saturated solution of potassium iodide remains a first line treatment choice for uncomplicated cutaneous sporotrichosis in resource poor countries but itraconazole is currently used/recommended for the treatment of all forms of sporotrichosis.

Terbinafine has been observed to be effective in the treatment of cutaneous sporotrichosis.

Amphotericin B is used initially for the treatment of severe, systemic disease, during pregnancy and in immunosuppressed patients until recovery, then followed by itraconazole for the rest of the therapy.

American Psychological Association (APA)

Mahajan, Vikram K.. 2014. Sporotrichosis: An Overview and Therapeutic Options. Dermatology Research and Practice،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1018043

Modern Language Association (MLA)

Mahajan, Vikram K.. Sporotrichosis: An Overview and Therapeutic Options. Dermatology Research and Practice No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1018043

American Medical Association (AMA)

Mahajan, Vikram K.. Sporotrichosis: An Overview and Therapeutic Options. Dermatology Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1018043

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1018043