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Gastrodia elata Ameliorates High-Fructose Diet-Induced Lipid Metabolism and Endothelial Dysfunction
Joint Authors
Kang, Dae Gill
Lee, Yun Jung
Kho, Min Chul
Choi, Kyung Min
Lee, Ho Sub
Cha, Jeong Dan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Overconsumption of fructose results in dyslipidemia, hypertension, and impaired glucose tolerance, which have documented correlation with metabolic syndrome.
Gastrodia elata, a widely used traditional herbal medicine, was reported with anti-inflammatory and antidiabetes activities.
Thus, this study examined whether ethanol extract of Gastrodia elata Blume (EGB) attenuate lipid metabolism and endothelial dysfunction in a high-fructose (HF) diet animal model.
Rats were fed the 65% HF diet with/without EGB 100 mg/kg/day for 8 weeks.
Treatment with EGB significantly suppressed the increments of epididymal fat weight, blood pressure, plasma triglyceride, total cholesterol levels, and oral glucose tolerance, respectively.
In addition, EGB markedly prevented increase of adipocyte size and hepatic accumulation of triglycerides.
EGB ameliorated endothelial dysfunction by downregulation of endothelin-1 (ET-1) and adhesion molecules in the aorta.
Moreover, EGB significantly recovered the impairment of vasorelaxation to acetylcholine and levels of endothelial nitric oxide synthase (eNOS) expression and induced markedly upregulation of phosphorylation AMP-activated protein kinase (AMPK)α in the liver, muscle, and fat.
These results indicate that EGB ameliorates dyslipidemia, hypertension, and insulin resistance as well as impaired vascular endothelial function in HF diet rats.
Taken together, EGB may be a beneficial therapeutic approach for metabolic syndrome.
American Psychological Association (APA)
Kho, Min Chul& Lee, Yun Jung& Cha, Jeong Dan& Choi, Kyung Min& Kang, Dae Gill& Lee, Ho Sub. 2014. Gastrodia elata Ameliorates High-Fructose Diet-Induced Lipid Metabolism and Endothelial Dysfunction. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1018079
Modern Language Association (MLA)
Kho, Min Chul…[et al.]. Gastrodia elata Ameliorates High-Fructose Diet-Induced Lipid Metabolism and Endothelial Dysfunction. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1018079
American Medical Association (AMA)
Kho, Min Chul& Lee, Yun Jung& Cha, Jeong Dan& Choi, Kyung Min& Kang, Dae Gill& Lee, Ho Sub. Gastrodia elata Ameliorates High-Fructose Diet-Induced Lipid Metabolism and Endothelial Dysfunction. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1018079
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018079