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Effects of Mentha suaveolens Essential Oil Alone or in Combination with Other Drugs in Candida albicans
Joint Authors
Stringaro, Annarita
Vavala, Elisabetta
Colone, Marisa
Pepi, Federico
Mignogna, Giuseppina
Garzoli, Stefania
Cecchetti, Serena
Ragno, Rino
Angiolella, Letizia
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Candidosis is the most important cause of fungal infections in humans.
The yeast Candida albicans can form biofilms, and it is known that microbial biofilms play an important role in human diseases and are very difficult to treat.
The prolonged treatment with drugs has often resulted in failure and resistance.
Due to the emergence of multidrug resistance, alternatives to conventional antimicrobial therapy are needed.
This study aims to analyse the effects induced by essential oil of Mentha suaveolens Ehrh (EOMS) on Candida albicans and its potential synergism when used in combination with conventional drugs.
Morphological differences between control and EOMS treated yeast cells or biofilms were observed by scanning electron microscopy and transmission electron microscopy (SEM and TEM resp.,).
In order to reveal the presence of cell cycle alterations, flow cytometry analysis was carried out as well.
The synergic action of EOMS was studied with the checkerboard method, and the cellular damage induced by different treatments was analysed by TEM.
The results obtained have demonstrated both the effects of EOMS on C.
albicans yeast cells and biofilms and the synergism of EOMS when used in combination with conventional antifungal drugs as fluconazole (FLC) and micafungin (MCFG), and therefore we can hypothesize on its potential use in therapy.
Further studies are necessary to know its mechanism of action.
American Psychological Association (APA)
Stringaro, Annarita& Vavala, Elisabetta& Colone, Marisa& Pepi, Federico& Mignogna, Giuseppina& Garzoli, Stefania…[et al.]. 2014. Effects of Mentha suaveolens Essential Oil Alone or in Combination with Other Drugs in Candida albicans. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1018105
Modern Language Association (MLA)
Stringaro, Annarita…[et al.]. Effects of Mentha suaveolens Essential Oil Alone or in Combination with Other Drugs in Candida albicans. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1018105
American Medical Association (AMA)
Stringaro, Annarita& Vavala, Elisabetta& Colone, Marisa& Pepi, Federico& Mignogna, Giuseppina& Garzoli, Stefania…[et al.]. Effects of Mentha suaveolens Essential Oil Alone or in Combination with Other Drugs in Candida albicans. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1018105
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018105