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Effects of Selenium-Enriched Protein from Ganoderma lucidum on the Levels of IL-1 β and TNF- α, Oxidative Stress, and NF- κB Activation in Ovalbumin-Induced Asthmatic Mice
Joint Authors
Min-chang, Guan
Wei-hong, Tang
Zhen, Xu
Jie, Sun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The purpose of this study was to compare the effect and toxicity of organic selenium (Pro-Se) with inorganic selenium (IOSe) in preventing asthma in ovalbumin-induced asthmatic mice.
After the mice were treated orally with Pro-Se and IOSe, respectively, the plasma Se levels, Se accumulation in liver and kidney, tumor necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1β), oxidative stress, and NF-κB activation in lung were examined.
The results showed that the serumal Se levels in the mice fed the Pro-Se were significant ( P < 0.01 ) elevations.
It results in restoration of the level of endogenous antioxidant enzyme, lower levels of TNF-α and IL-1β, and activated NF-κB in the asthmatic mice.
Our experiments have demonstrated profound differences between the activities of organic selenium and inorganic selenium in experimental conditions.
These data provide an important proof of the concept that organic selenium might be a new potential therapy for the management of childhood asthma in humans.
American Psychological Association (APA)
Min-chang, Guan& Wei-hong, Tang& Zhen, Xu& Jie, Sun. 2014. Effects of Selenium-Enriched Protein from Ganoderma lucidum on the Levels of IL-1 β and TNF- α, Oxidative Stress, and NF- κB Activation in Ovalbumin-Induced Asthmatic Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1018191
Modern Language Association (MLA)
Min-chang, Guan…[et al.]. Effects of Selenium-Enriched Protein from Ganoderma lucidum on the Levels of IL-1 β and TNF- α, Oxidative Stress, and NF- κB Activation in Ovalbumin-Induced Asthmatic Mice. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1018191
American Medical Association (AMA)
Min-chang, Guan& Wei-hong, Tang& Zhen, Xu& Jie, Sun. Effects of Selenium-Enriched Protein from Ganoderma lucidum on the Levels of IL-1 β and TNF- α, Oxidative Stress, and NF- κB Activation in Ovalbumin-Induced Asthmatic Mice. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1018191
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018191