Diarylheptanoids from Alpinia officinarum Cause Distinct but Overlapping Effects on the Translatome of B Lymphoblastoid Cells
Joint Authors
Kakegawa, Tomohito
Takase, Saeko
Masubuchi, Eri
Yasukawa, Ken
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Diarylheptanoids (AO-0001, AO-0002, and AO-0003) isolated from Alpinia officinarum inhibit proinflammatory mediators and exhibit cytotoxic and antiviral activity.
However, the precise mechanisms of action of these diarylheptanoids are unknown as are their effects on expression of specific genes.
Here, we used a translatome analysis to investigate the mechanisms and modes of action of these three diarylheptanoids.
Polysome-associated messenger RNAs (mRNAs) were prepared from diarylheptanoids-treated and control cells from a human B lymphoblastoid cell line; these mRNA samples were then used for microarray analysis.
Microarray Data Analysis Tool version 3.2 was used to analyze the microarray data analysis; this software uses pathway information of the WikiPathways for gene ontology analysis.
Each of the diarylheptanoids caused upregulation or downregulation of the same 37 and 286 genes, respectively.
Among the 37 upregulated genes, 16 were related to mRNA processing based on the WikiPathways analysis.
Our findings provided new insights into the mode of action of diarylheptanoids from A.
officinarum.
American Psychological Association (APA)
Kakegawa, Tomohito& Takase, Saeko& Masubuchi, Eri& Yasukawa, Ken. 2014. Diarylheptanoids from Alpinia officinarum Cause Distinct but Overlapping Effects on the Translatome of B Lymphoblastoid Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1018220
Modern Language Association (MLA)
Kakegawa, Tomohito…[et al.]. Diarylheptanoids from Alpinia officinarum Cause Distinct but Overlapping Effects on the Translatome of B Lymphoblastoid Cells. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1018220
American Medical Association (AMA)
Kakegawa, Tomohito& Takase, Saeko& Masubuchi, Eri& Yasukawa, Ken. Diarylheptanoids from Alpinia officinarum Cause Distinct but Overlapping Effects on the Translatome of B Lymphoblastoid Cells. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1018220
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018220