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Acupuncture Stimulation Attenuates Impaired Emotional-Like Behaviors and Activation of the Noradrenergic System during Protracted Abstinence following Chronic Morphine Exposure in Rats
Joint Authors
Shim, Insop
Lee, Hyejung
Lee, Bombi
Sur, Bong-Jun
Hahm, Dae-Hyun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-09
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
The purpose of this study was to evaluate whether acupuncture stimulation attenuates withdrawal-induced behaviors in the rats during protracted abstinence following chronic morphine exposure.
To do this, male rats were first exposed to morphine gradually from 20 to 100 mg/kg for 5 days, and subsequently naloxone was injected once to extend despair-related withdrawal behaviors for 4 weeks.
Acupuncture stimulation was performed once at the SP6 (Sanyinjiao) acupoint on rat’s; hind leg for 5 min during protracted abstinence from morphine.
The acupuncture stimulation significantly decreased despair-like behavior deficits in the forced swimming test and low sociability in the open-field test as well as increased open-arm exploration in the elevated plus maze test in the last week of 4-week withdrawal period.
Also the acupuncture stimulation significantly suppressed the increase in the hypothalamic corticotropin-releasing factor (CRF) expression, the decrease in the tyrosine hydroxylase expression in the locus coeruleus, and the decrease in the hippocampal brain-derived neurotrophic factor mRNA expression, induced by repeated injection of morphine.
Taken together, these findings demonstrate that the acupuncture stimulation of SP6 significantly reduces withdrawal-induced behaviors, induced by repeated administration of morphine in rats, possibly through the modulation of hypothalamic CRF and the central noradrenergic system.
American Psychological Association (APA)
Lee, Bombi& Sur, Bong-Jun& Shim, Insop& Hahm, Dae-Hyun& Lee, Hyejung. 2014. Acupuncture Stimulation Attenuates Impaired Emotional-Like Behaviors and Activation of the Noradrenergic System during Protracted Abstinence following Chronic Morphine Exposure in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-1018242
Modern Language Association (MLA)
Lee, Bombi…[et al.]. Acupuncture Stimulation Attenuates Impaired Emotional-Like Behaviors and Activation of the Noradrenergic System during Protracted Abstinence following Chronic Morphine Exposure in Rats. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-17.
https://search.emarefa.net/detail/BIM-1018242
American Medical Association (AMA)
Lee, Bombi& Sur, Bong-Jun& Shim, Insop& Hahm, Dae-Hyun& Lee, Hyejung. Acupuncture Stimulation Attenuates Impaired Emotional-Like Behaviors and Activation of the Noradrenergic System during Protracted Abstinence following Chronic Morphine Exposure in Rats. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-1018242
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018242