Coenzyme Q0 from Antrodia cinnamomea in Submerged Cultures Induces Reactive Oxygen Species-Mediated Apoptosis in A549 Human Lung Cancer Cells
Joint Authors
Chung, Cheng-Han
Yeh, Szu-Chien
Chen, Chun-Jen
Lee, Kung-Ta
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-06
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
We investigated the anticancer effects of Antrodia cinnamomea, a medicinal mushroom from Taiwan, on A549 human lung cancer cells using the ethyl acetate extract from submerged culture filtrates.
Our results showed that 2,3-dimethoxy-5-methyl-1,4-benzoquinone (coenzyme Q0; CoQ0) derived from A.
cinnamomea submerged culture filtrates has anticancer activity.
CoQ0 treatment reduced the viability of A549, HepG2, and SW480 cancer cell lines.
Furthermore, CoQ0 induced reactive oxygen species (ROS) generation and apoptosis in A549 cells, which was inhibited by the antioxidant ascorbic acid.
To our knowledge, these data demonstrate for the first time that CoQ0 derived from A.
cinnamomea submerged culture filtrates exerts its anticancer effect through the induction of ROS-mediated apoptosis in A549 human lung cancer cells.
American Psychological Association (APA)
Chung, Cheng-Han& Yeh, Szu-Chien& Chen, Chun-Jen& Lee, Kung-Ta. 2014. Coenzyme Q0 from Antrodia cinnamomea in Submerged Cultures Induces Reactive Oxygen Species-Mediated Apoptosis in A549 Human Lung Cancer Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1018268
Modern Language Association (MLA)
Chung, Cheng-Han…[et al.]. Coenzyme Q0 from Antrodia cinnamomea in Submerged Cultures Induces Reactive Oxygen Species-Mediated Apoptosis in A549 Human Lung Cancer Cells. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1018268
American Medical Association (AMA)
Chung, Cheng-Han& Yeh, Szu-Chien& Chen, Chun-Jen& Lee, Kung-Ta. Coenzyme Q0 from Antrodia cinnamomea in Submerged Cultures Induces Reactive Oxygen Species-Mediated Apoptosis in A549 Human Lung Cancer Cells. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1018268
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018268
