Effect of Gloriosa superba and Catharanthus roseus Extracts on IFN-γ-Induced Keratin 17 Expression in HaCaT Human Keratinocytes
Joint Authors
Tencomnao, Tewin
Pattarachotanant, Nattaporn
Rakkhitawatthana, Varaporn
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Gloriosa superba and Catharanthus roseus are useful in traditional medicine for treatment of various skin diseases and cancer.
However, their molecular effect on psoriasis has not been investigated.
In this study, the effect of ethanol extracts derived from G.
superba leaves and C.
roseus stems on the expression of psoriatic marker, keratin 17 (K17), was investigated in human keratinocytes using biochemical and molecular experimental approaches.
Both extracts could reduce the expression of K17 in a dose-dependent manner through JAK/STAT pathway as demonstrated by an observation of reduced phosphorylation of STAT3 (p-STAT3).
The inhibitory activity of G.
superba extract was more potent than that of C.
roseus.
The Pearson's correlation between K17 and cell viability was shown positive.
Taken together, the extracts of G.
superba and C.
roseus may be developed as alternative therapies for psoriasis.
American Psychological Association (APA)
Pattarachotanant, Nattaporn& Rakkhitawatthana, Varaporn& Tencomnao, Tewin. 2014. Effect of Gloriosa superba and Catharanthus roseus Extracts on IFN-γ-Induced Keratin 17 Expression in HaCaT Human Keratinocytes. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1018272
Modern Language Association (MLA)
Pattarachotanant, Nattaporn…[et al.]. Effect of Gloriosa superba and Catharanthus roseus Extracts on IFN-γ-Induced Keratin 17 Expression in HaCaT Human Keratinocytes. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1018272
American Medical Association (AMA)
Pattarachotanant, Nattaporn& Rakkhitawatthana, Varaporn& Tencomnao, Tewin. Effect of Gloriosa superba and Catharanthus roseus Extracts on IFN-γ-Induced Keratin 17 Expression in HaCaT Human Keratinocytes. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1018272
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018272
