Investigation of the Novel Lead of Melanocortin 1 Receptor for Pigmentary Disorders
Joint Authors
Chen, Calvin Yu-Chian
Tang, Hsin-Chieh
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-17
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Knowing the role of MC1R in skin tanning can provide a brand new idea to resolve pigmentary disorders.
αMSH has 13 amino acids and is the most essential pigmentary melanocortin responsible for melanin synthesis.
One could utilize the compound library to find lead compounds by virtual screening from peptide database and traditional Chinese medicine (TCM) database@Taiwan.
Computational simulation provided a convenient technology to survey potential lead.
Ligand-based validation set up the reliable model for molecular dynamics simulation.
Molecular dynamics simulation approved the binding affinity and stability of the peptides selected by virtual screening.
Thus, we concluded that Glu-Glu-Lys-Glu (EEKE), Glu-Gly-Gly-Ser-Val-Glu-Ser (EGGSVES), and Glu-Glu-Asp-Cys-Lys (EEDCK) were potent lead peptides for MC1R to resolve pigmentary disorders.
American Psychological Association (APA)
Tang, Hsin-Chieh& Chen, Calvin Yu-Chian. 2014. Investigation of the Novel Lead of Melanocortin 1 Receptor for Pigmentary Disorders. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1018291
Modern Language Association (MLA)
Tang, Hsin-Chieh& Chen, Calvin Yu-Chian. Investigation of the Novel Lead of Melanocortin 1 Receptor for Pigmentary Disorders. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1018291
American Medical Association (AMA)
Tang, Hsin-Chieh& Chen, Calvin Yu-Chian. Investigation of the Novel Lead of Melanocortin 1 Receptor for Pigmentary Disorders. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1018291
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018291