Curcumin Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm by Inhibition of Inflammatory Response and ERK Signaling Pathways
Joint Authors
Hao, QingQing
Chen, Xu
Wang, XiaoYu
Dong, Bo
Yang, ChuanHua
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Curcumin has long been used to treat age-related diseases, such as atherosclerosis and coronary heart disease.
In this study, we explored the effects of curcumin on the development of abdominal aortic aneurysm (AAA).
Methods.
ApoE−/− mice were randomly divided into 3 groups: AngII group, AngII + curcumin (AngII + Cur) group (100 mg/kg/d), and the control group.
Miniosmotic pumps were implanted subcutaneously in ApoE−/− mice to deliver AngII for 28 days.
After 4-week treatment, abdominal aortas with AAA were obtained for H&E staining, immunohistochemistry, and Western blotting.
Results.
The results showed that curcumin treatment significantly decreased the occurrence of AAA.
The levels of macrophage infiltration, monocyte chemoattractant protein-1 (MCP-1), and tumor necrosis factors-α (TNF-α) were significantly lower in AngII + Cur group than those in AngII group (all P<0.01).
The level of superoxide dismutase (SOD) was significantly higher in AngII + Cur group than those in AngII group P<0.01.
The ERK1/2 phosphorylation in AngII + Cur group was significantly lower than that in AngII group P<0.01.
Conclusions.
These results suggested that curcumin can inhibit the AngII-induced AAA in ApoE−/− mice, whose mechanisms include the curcumin anti-inflammation, antioxidative stress, and downregulation of ERK signaling pathway.
American Psychological Association (APA)
Hao, QingQing& Chen, Xu& Wang, XiaoYu& Dong, Bo& Yang, ChuanHua. 2014. Curcumin Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm by Inhibition of Inflammatory Response and ERK Signaling Pathways. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1018313
Modern Language Association (MLA)
Hao, QingQing…[et al.]. Curcumin Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm by Inhibition of Inflammatory Response and ERK Signaling Pathways. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1018313
American Medical Association (AMA)
Hao, QingQing& Chen, Xu& Wang, XiaoYu& Dong, Bo& Yang, ChuanHua. Curcumin Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm by Inhibition of Inflammatory Response and ERK Signaling Pathways. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1018313
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018313