Astragalus Polysaccharide Protects Astrocytes from Being Infected by HSV-1 through TLR3NF- κ B Signaling Pathway
Joint Authors
Shi, Lihong
Yin, Fengling
Xin, Xiangui
Mao, Shumei
Hu, Pingping
Zhao, Chunzhen
Sun, Xiuning
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Astragalus polysaccharide (APS) is the most immunoreactive substance in Astragalus.
APS can regulate the body’s immunity and is widely used in many immune related diseases.
However, till now, there is little information about its contribution to the protection of astrocytes infected by virus.
Toll-like receptor 3 (TLR3) is a key component of the innate immune system and has the ability to detect virus infection and trigger host defence responses.
This study was undertaken to elucidate the protective effect of APS on herpes simplex virus (HSV-1) infected astrocytes and the underlying mechanisms.
The results showed that APS protected the astrocytes from HSV-1 induced proliferation inhibition along with increasing expression of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) markedly.
Moreover, APS significantly promoted the expression of Toll-like receptor 3 (TLR3) and the activation of nuclear factor-κB (NF-κB) in astrocytes.
In addition, while astrocytes were pretreated with TLR3 antibody before adding HSV-1 and APS, the expression of TLR3, TNF-α, and IL-6 and the activation of NF-κB decreased sharply.
These results indicate that APS can protect astrocytes by promoting immunological function provoked by HSV-1 through TLR3/NF-κB pathway.
American Psychological Association (APA)
Shi, Lihong& Yin, Fengling& Xin, Xiangui& Mao, Shumei& Hu, Pingping& Zhao, Chunzhen…[et al.]. 2014. Astragalus Polysaccharide Protects Astrocytes from Being Infected by HSV-1 through TLR3NF- κ B Signaling Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1018336
Modern Language Association (MLA)
Shi, Lihong…[et al.]. Astragalus Polysaccharide Protects Astrocytes from Being Infected by HSV-1 through TLR3NF- κ B Signaling Pathway. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1018336
American Medical Association (AMA)
Shi, Lihong& Yin, Fengling& Xin, Xiangui& Mao, Shumei& Hu, Pingping& Zhao, Chunzhen…[et al.]. Astragalus Polysaccharide Protects Astrocytes from Being Infected by HSV-1 through TLR3NF- κ B Signaling Pathway. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1018336
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018336