Antioxidant and Anti-Inflammatory Activities of Berberine in the Treatment of Diabetes Mellitus
Joint Authors
Li, Zheng
Geng, Ya-Na
Jiang, Jian-Dong
Kong, Wei-Jia
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-11
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Oxidative stress and inflammation are proved to be critical for the pathogenesis of diabetes mellitus.
Berberine (BBR) is a natural compound isolated from plants such as Coptis chinensis and Hydrastis canadensis and with multiple pharmacological activities.
Recent studies showed that BBR had antioxidant and anti-inflammatory activities, which contributed in part to its efficacy against diabetes mellitus.
In this review, we summarized the antioxidant and anti-inflammatory activities of BBR as well as their molecular basis.
The antioxidant and anti-inflammatory activities of BBR were noted with changes in oxidative stress markers, antioxidant enzymes, and proinflammatory cytokines after BBR administration in diabetic animals.
BBR inhibited oxidative stress and inflammation in a variety of tissues including liver, adipose tissue, kidney and pancreas.
Mechanisms of the antioxidant and anti-inflammatory activities of BBR were complex, which involved multiple cellular kinases and signaling pathways, such as AMP-activated protein kinase (AMPK), mitogen-activated protein kinases (MAPKs), nuclear factor erythroid-2-related factor-2 (Nrf2) pathway, and nuclear factor-κB (NF-κB) pathway.
Detailed mechanisms and pathways for the antioxidant and anti-inflammatory activities of BBR still need further investigation.
Clarification of these issues could help to understand the pharmacology of BBR in the treatment of diabetes mellitus and promote the development of antidiabetic natural products.
American Psychological Association (APA)
Li, Zheng& Geng, Ya-Na& Jiang, Jian-Dong& Kong, Wei-Jia. 2014. Antioxidant and Anti-Inflammatory Activities of Berberine in the Treatment of Diabetes Mellitus. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1018342
Modern Language Association (MLA)
Li, Zheng…[et al.]. Antioxidant and Anti-Inflammatory Activities of Berberine in the Treatment of Diabetes Mellitus. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1018342
American Medical Association (AMA)
Li, Zheng& Geng, Ya-Na& Jiang, Jian-Dong& Kong, Wei-Jia. Antioxidant and Anti-Inflammatory Activities of Berberine in the Treatment of Diabetes Mellitus. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1018342
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018342