Effect of ASF (a Compound of Traditional Chinese Medicine) on Behavioral Sensitization Induced by Ethanol and Conditioned Place Preference in Mice
Joint Authors
Wen, Da-chao
Li, Yi-bei
Hu, Xiao-Yu
Lin, Wu
Jia, Ling-yan
Zhong, Sen
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
ASF composed by semen and epimedium herbal is a traditional plant compound that is widely used in the treatment of insomnia.
Studies have shown that saponins and flavonoids contained in semen can significantly decrease the content of excitatory neurotransmitter Glu in mice.
And the total flavone of YinYangHuo can increase the release of GABA in the anterior periventricular system of rat and increase the affinity of GABA for the receptors GABAA.
It can be inferred that their synergism may have effect on the neurotransmitter that causes behavioral sensitization and conditioned place preference in experimental animals and affects their drinking behaviors, which is the starting point of this research.
The present study found that ASF can inhibit development and expression of behavioral sensitization induced by ethanol and the development of CPP in mice.
We demonstrate the inhibition of ASF on behavioral sensitization partly due to its effect on the mesolimbic neurotransmitter system, including decreasing level of DA and Glu and increasing the content of GABA.
It suggested that the ASF may have pharmacological effects in the treatment of alcohol addiction.
American Psychological Association (APA)
Wen, Da-chao& Li, Yi-bei& Hu, Xiao-Yu& Lin, Wu& Jia, Ling-yan& Zhong, Sen. 2014. Effect of ASF (a Compound of Traditional Chinese Medicine) on Behavioral Sensitization Induced by Ethanol and Conditioned Place Preference in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1018351
Modern Language Association (MLA)
Wen, Da-chao…[et al.]. Effect of ASF (a Compound of Traditional Chinese Medicine) on Behavioral Sensitization Induced by Ethanol and Conditioned Place Preference in Mice. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1018351
American Medical Association (AMA)
Wen, Da-chao& Li, Yi-bei& Hu, Xiao-Yu& Lin, Wu& Jia, Ling-yan& Zhong, Sen. Effect of ASF (a Compound of Traditional Chinese Medicine) on Behavioral Sensitization Induced by Ethanol and Conditioned Place Preference in Mice. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1018351
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018351