Intracellular ROS Scavenging Activity and Downregulation of Inflammatory Mediators in RAW264.7 Macrophage by Fresh Leaf Extracts of Pseuderanthemum palatiferum
Joint Authors
Sittisart, Patcharawan
Chitsomboon, Benjamart
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-16
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Beneficial antioxidant phytochemicals are found in many medicinal plants.
Pseuderanthemum palatiferum (PP), a well-known Vietnamese traditional medicinal plant in Thailand, has long been used in folk medicine for curing inflammatory diseases, often with limited support of scientific research.
Therefore, this study aimed to determine antioxidant and modulation of inflammatory mediators of ethanol and water extracts of PP (EEP and WEP, resp.).
WEP had significantly higher phenolic and flavonoid levels and DPPH radical scavenging activity than EEP.
However, EEP exhibited greater reducing power than WEP.
A greater decrease of tert-butyl hydroperoxide-induced oxidative stress in RAW264.7 macrophage cells was also observed with EEP.
Modulation of inflammatory mediators of EEP and WEP was evaluated on LPS plus IFN-γ-stimulated RAW264.7 cells.
EEP more potently suppressed LPS plus IFN-γ-induced nitric oxide (NO) production than WEP.
Both EEP and WEP also suppressed the expression of iNOS and COX-2 protein levels.
Collectively, these results suggest that PP possesses strong antioxidant and anti-inflammatory properties.
American Psychological Association (APA)
Sittisart, Patcharawan& Chitsomboon, Benjamart. 2014. Intracellular ROS Scavenging Activity and Downregulation of Inflammatory Mediators in RAW264.7 Macrophage by Fresh Leaf Extracts of Pseuderanthemum palatiferum. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1018355
Modern Language Association (MLA)
Sittisart, Patcharawan& Chitsomboon, Benjamart. Intracellular ROS Scavenging Activity and Downregulation of Inflammatory Mediators in RAW264.7 Macrophage by Fresh Leaf Extracts of Pseuderanthemum palatiferum. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1018355
American Medical Association (AMA)
Sittisart, Patcharawan& Chitsomboon, Benjamart. Intracellular ROS Scavenging Activity and Downregulation of Inflammatory Mediators in RAW264.7 Macrophage by Fresh Leaf Extracts of Pseuderanthemum palatiferum. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1018355
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018355