Safety and Tolerability of Essential Oil from Cinnamomum zeylanicum Blume Leaves with Action on Oral Candidosis and Its Effect on the Physical Properties of the Acrylic Resin
Joint Authors
Cavalcanti, Alessandro Leite
Oliveira, Julyana de Araújo
da Silva, Ingrid Carla Guedes
Trindade, Leonardo Antunes
Lima, Edeltrudes Oliveira
Carlo, Hugo Lemes
Castro, Ricardo Dias de
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The anti-Candida activity of essential oil from Cinnamomum zeylanicum Blume, as well as its effect on the roughness and hardness of the acrylic resin used in dental prostheses, was assessed.
The safety and tolerability of the test product were assessed through a phase I clinical trial involving users of removable dentures.
Minimum inhibitory concentration (MIC) and minimum fungicidal concentrations (MFC) were determined against twelve Candida strains.
Acrylic resin specimens were exposed to artificial saliva (GI), C.
zeylanicum (GII), and nystatin (GIII) for 15 days.
Data were submitted to ANOVA and Tukey posttest (α=5%).
For the phase I clinical trial, 15 healthy patients used solution of C.
zeylanicum at MIC (15 days, 3 times a day) and were submitted to clinical and mycological examinations.
C.
zeylanicum showed anti-Candida activity, with MIC = 625.0 µg/mL being equivalent to MFC.
Nystatin caused greater increase in roughness and decreased the hardness of the material (P<0.0001), with no significant differences between GI and GII.
As regards the clinical trial, no adverse clinical signs were observed after intervention.
The substance tested had a satisfactory level of safety and tolerability, supporting new advances involving the clinical use of essential oil from C.
zeylanicum.
American Psychological Association (APA)
Oliveira, Julyana de Araújo& da Silva, Ingrid Carla Guedes& Trindade, Leonardo Antunes& Lima, Edeltrudes Oliveira& Carlo, Hugo Lemes& Cavalcanti, Alessandro Leite…[et al.]. 2014. Safety and Tolerability of Essential Oil from Cinnamomum zeylanicum Blume Leaves with Action on Oral Candidosis and Its Effect on the Physical Properties of the Acrylic Resin. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1018369
Modern Language Association (MLA)
Oliveira, Julyana de Araújo…[et al.]. Safety and Tolerability of Essential Oil from Cinnamomum zeylanicum Blume Leaves with Action on Oral Candidosis and Its Effect on the Physical Properties of the Acrylic Resin. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1018369
American Medical Association (AMA)
Oliveira, Julyana de Araújo& da Silva, Ingrid Carla Guedes& Trindade, Leonardo Antunes& Lima, Edeltrudes Oliveira& Carlo, Hugo Lemes& Cavalcanti, Alessandro Leite…[et al.]. Safety and Tolerability of Essential Oil from Cinnamomum zeylanicum Blume Leaves with Action on Oral Candidosis and Its Effect on the Physical Properties of the Acrylic Resin. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1018369
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018369