Huperzine A in the Treatment of Alzheimer's Disease and Vascular Dementia: A Meta-Analysis
Joint Authors
Xing, Shu-huai
Zhu, Chun-xiao
Zhang, Rui
An, Li
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The objective of our study was to perform an updated meta-analysis of placebo-controlled RCTs of Huperzine A (Hup A) on patients with Alzheimer's disease (AD) and vascular dementia (VD), in order to provide the basis and reference for clinical rational drug use.
The primary outcome measures assessed were minimental state examination (MMSE) and activities of daily living scale (ADL).
Eight AD trials with 733 participants and two VD trials with 92 participants that met our inclusion criteria were identified.
The results showed that Hup A could significantly improve the MMSE and ADL score of AD and VD patients, and longer durations would result in better efficacy for the patients with AD.
It seemed that there was significant improvement of cognitive function measured by memory quotient (MQ) in patients with AD.
Most adverse effects in AD were generally of mild to moderate severity and transient.
Compared to the patients with AD, Hup A may offer fewer side effects for participants with VD in this study.
Therefore, Hup A is a well-tolerated drug that could significantly improve cognitive performance in patients with AD or VD, but we need to use it with caution in the clinical treatment.
American Psychological Association (APA)
Xing, Shu-huai& Zhu, Chun-xiao& Zhang, Rui& An, Li. 2014. Huperzine A in the Treatment of Alzheimer's Disease and Vascular Dementia: A Meta-Analysis. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1018390
Modern Language Association (MLA)
Xing, Shu-huai…[et al.]. Huperzine A in the Treatment of Alzheimer's Disease and Vascular Dementia: A Meta-Analysis. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1018390
American Medical Association (AMA)
Xing, Shu-huai& Zhu, Chun-xiao& Zhang, Rui& An, Li. Huperzine A in the Treatment of Alzheimer's Disease and Vascular Dementia: A Meta-Analysis. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1018390
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018390