Immunosuppressive Effects of A-Type Procyanidin Oligomers from Cinnamomum tamala
Joint Authors
Chen, Liang
Yang, Yang
Yuan, Pulong
Yang, Yifu
Chen, Kaixian
Jia, Qi
Li, Yiming
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Cinnamon barks extracts have been reported to regulate immune function; however, the component(s) in cinnamon barks responsible for this effect is/are not yet clear.
The aim of this study is to find out the possible component(s) that can be used as therapeutic agents for immune-related diseases from cinnamon bark.
In this study, the immunosuppressive effects of fraction (named CT-F) and five procyanidin oligomers compounds, cinnamtannin B1, cinnamtannin D1 (CTD-1), parameritannin A1, procyanidin B2, and procyanidin C1, from Cinnamomum tamala or Cinnamomum cassia bark were examined on splenocytes proliferation model induced by ConA or LPS.
Then, the effects of activated compound CTD-1 on cytokine production and 2,4-dinitrofluorobenzene (DNFB) induced delayed-type hypersensitivity (DTH) response were detected to evaluate the immunosuppressive activity of CTD-1.
It was found that CT-F and CTD-1 significantly inhibited the splenocyte proliferation induced by ConA or LPS.
CTD-1 dose-dependently reduced the level of IFN- γ and IL-2 and intensively suppressed DNFB-induced DTH responses.
These findings suggest that the immunosuppressive activities of cinnamon bark are in part due to procyanidin oligomers.
CTD-1 may be a potential therapeutic agent for immune-related diseases.
American Psychological Association (APA)
Chen, Liang& Yang, Yang& Yuan, Pulong& Yang, Yifu& Chen, Kaixian& Jia, Qi…[et al.]. 2014. Immunosuppressive Effects of A-Type Procyanidin Oligomers from Cinnamomum tamala. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1018392
Modern Language Association (MLA)
Chen, Liang…[et al.]. Immunosuppressive Effects of A-Type Procyanidin Oligomers from Cinnamomum tamala. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1018392
American Medical Association (AMA)
Chen, Liang& Yang, Yang& Yuan, Pulong& Yang, Yifu& Chen, Kaixian& Jia, Qi…[et al.]. Immunosuppressive Effects of A-Type Procyanidin Oligomers from Cinnamomum tamala. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1018392
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018392