Acupoint-Specific, Frequency-Dependent, and Improved Insulin Sensitivity Hypoglycemic Effect of Electroacupuncture Applied to Drug-Combined Therapy Studied by a Randomized Control Clinical Trial
Joint Authors
Chen, Ying-I
Chang, Shih-Liang
Hsu, Tai-Hao
Lin, Rong-Tsung
Lin, Jaung Geng
Lee, Yu-Chen
Tzeng, Chung-Yuh
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The application of electroacupuncture (EA) to specific acupoints can induce a hypoglycemic effect in streptozotocin-induced rats, normal rats, and rats with steroid-induced insulin resistance.
EA combined with the oral insulin sensitizer rosiglitazone improved insulin sensitivity in rats and humans with type II diabetes mellitus (DM).
There are different hypoglycemic mechanisms between Zhongwan and Zusanli acupoints by EA stimulation.
On low-frequency (2 Hz) stimulation at bilateral Zusanli acupoints, serotonin was involved in the hypoglycemic effect in normal rats.
Moreover, after 15 Hz EA stimulation at the bilateral Zusanli acupoints, although enhanced insulin activity mainly acts on the insulin-sensitive target organs, the muscles must be considered.
In addition, 15 Hz EA stimulation at the bilateral Zusanli acupoints has the combined effect of enhancing cholinergic nerve activity and increasing nitric oxide synthase (NOS) activity to enhance insulin activity.
Despite the well-documented effect of pain control by EA in many systemic diseases, there are few high-quality long-term clinical trials on the hypoglycemic effect of EA in DM.
Combination treatment with EA and other medications seems to be an alternative treatment to achieve better therapeutic goals that merit future investigation.
American Psychological Association (APA)
Lin, Rong-Tsung& Tzeng, Chung-Yuh& Lee, Yu-Chen& Chen, Ying-I& Hsu, Tai-Hao& Lin, Jaung Geng…[et al.]. 2014. Acupoint-Specific, Frequency-Dependent, and Improved Insulin Sensitivity Hypoglycemic Effect of Electroacupuncture Applied to Drug-Combined Therapy Studied by a Randomized Control Clinical Trial. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1018402
Modern Language Association (MLA)
Lin, Rong-Tsung…[et al.]. Acupoint-Specific, Frequency-Dependent, and Improved Insulin Sensitivity Hypoglycemic Effect of Electroacupuncture Applied to Drug-Combined Therapy Studied by a Randomized Control Clinical Trial. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1018402
American Medical Association (AMA)
Lin, Rong-Tsung& Tzeng, Chung-Yuh& Lee, Yu-Chen& Chen, Ying-I& Hsu, Tai-Hao& Lin, Jaung Geng…[et al.]. Acupoint-Specific, Frequency-Dependent, and Improved Insulin Sensitivity Hypoglycemic Effect of Electroacupuncture Applied to Drug-Combined Therapy Studied by a Randomized Control Clinical Trial. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1018402
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018402