Auraptene in the Peels of Citrus kawachiensis (Kawachi Bankan) Ameliorates Lipopolysaccharide-Induced Inflammation in the Mouse Brain
Joint Authors
Okuyama, Satoshi
Yamamoto, Kana
Mori, Hirotomo
Toyoda, Nobuki
Yoshimura, Morio
Amakura, Yoshiaki
Yoshida, Takashi
Sugawara, Kuniaki
Sudo, Masahiko
Nakajima, Mitsunari
Furukawa, Yoshiko
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Examination of the dried peel powder of Citrus kawachiensis, one of the citrus products of Ehime, Japan, showed that it contained naringin (NGIN; 44.02 ± 0.491 mg/g), narirutin (NRTN; 4.46 ± 0.0563 mg/g), auraptene (AUR; 4.07 ± 0.033 mg/g), and 3,5,6,7,8,3′,4′-heptamethoxyflavone (HMF; 0.27 ± 0.0039 mg/g).
When this dried peel powder was orally preadministered at the dose of 1.2 or 2.4 g/kg/day for 7 days into lipopolysaccharide- (LPS-) injected mice, an animal model of systemic inflammation, it suppressed (1) LPS-induced loss of body weight and abnormal behavior in the open field, (2) LPS-induced activation of microglia and astrocytes in the hippocampus, and (3) LPS-induced expression of cyclooxygenase (COX)-2, which were coexpressed in astrocytes of these mice.
When NGIN or AUR was preadministered to LPS-injected mice at an amount similar to that in the peel powder, AUR, but not NGIN, had the ability to suppress the LPS-induced inflammation in the brain of these model mice.
The dried powder of flavedo tissue (the outer colored layer of the mesocarp of a citrus fruit) and juice, which contained sufficient amounts of AUR, also had anti-inflammatory effect.
These results suggest that AUR was the main ingredient responsible for the anti-inflammatory property of the dried peels of C.
kawachiensis.
American Psychological Association (APA)
Okuyama, Satoshi& Yamamoto, Kana& Mori, Hirotomo& Toyoda, Nobuki& Yoshimura, Morio& Amakura, Yoshiaki…[et al.]. 2014. Auraptene in the Peels of Citrus kawachiensis (Kawachi Bankan) Ameliorates Lipopolysaccharide-Induced Inflammation in the Mouse Brain. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1018453
Modern Language Association (MLA)
Okuyama, Satoshi…[et al.]. Auraptene in the Peels of Citrus kawachiensis (Kawachi Bankan) Ameliorates Lipopolysaccharide-Induced Inflammation in the Mouse Brain. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1018453
American Medical Association (AMA)
Okuyama, Satoshi& Yamamoto, Kana& Mori, Hirotomo& Toyoda, Nobuki& Yoshimura, Morio& Amakura, Yoshiaki…[et al.]. Auraptene in the Peels of Citrus kawachiensis (Kawachi Bankan) Ameliorates Lipopolysaccharide-Induced Inflammation in the Mouse Brain. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1018453
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018453