![](/images/graphics-bg.png)
Gyejigachulbu-Tang Relieves Oxaliplatin-Induced Neuropathic Cold and Mechanical Hypersensitivity in Rats via the Suppression of Spinal Glial Activation
Joint Authors
Min, Byung-Il
Hwang, Deok-Sang
Ahn, Byung-Soo
Kim, Seong-Kyu
Kim, Ha Neul
Lee, Ji-Hye
Lee, Ji-Hwan
Bae, Hyunsu
Kim, Sun Kwang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Activation of spinal glial cells plays a crucial role in the pathogenesis of neuropathic pain.
An administration of oxaliplatin, an important anticancer drug, often induces acute neuropathic cold hypersensitivity and/or mechanical hypersensitivity in patients.
Gyejigachulbu-tang (GBT), a herbal formula comprising Cinnamomi Cortex, Paeoniae Radix, Atractylodis Lanceae Rhizoma, Zizyphi Fructus, Glycyrrhizae Radix, Zingiberis Rhizoma, and Aconiti Tuber, has been used in East Asia to treat various pain symptoms, especially in cold patients.
This study investigated whether and how GBT alleviates oxaliplatin-induced cold and mechanical hypersensitivity in rats.
The behavioral signs of cold and mechanical hypersensitivity were evaluated by a tail immersion test in cold water (4°C) and a von Frey hair test, respectively.
The significant cold and mechanical hypersensitivity were observed 3 days after an oxaliplatin injection (6 mg/kg, i.p.).
Daily oral administration of GBT (200, 400, and 600 mg/kg) for 5 days markedly attenuated cold and mechanical hypersensitivity.
Immunoreactivities of glial fibrillary acidic protein (GFAP, astrocyte marker) and OX-42 (microglia marker) in the spinal dorsal horn were significantly increased by an oxaliplatin injection, which were restored by GBT administration.
These results indicate that GBT relieves oxaliplatin-induced cold and mechanical hypersensitivity in rats possibly through the suppression of spinal glial activation.
American Psychological Association (APA)
Ahn, Byung-Soo& Kim, Seong-Kyu& Kim, Ha Neul& Lee, Ji-Hye& Lee, Ji-Hwan& Hwang, Deok-Sang…[et al.]. 2014. Gyejigachulbu-Tang Relieves Oxaliplatin-Induced Neuropathic Cold and Mechanical Hypersensitivity in Rats via the Suppression of Spinal Glial Activation. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1018471
Modern Language Association (MLA)
Ahn, Byung-Soo…[et al.]. Gyejigachulbu-Tang Relieves Oxaliplatin-Induced Neuropathic Cold and Mechanical Hypersensitivity in Rats via the Suppression of Spinal Glial Activation. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1018471
American Medical Association (AMA)
Ahn, Byung-Soo& Kim, Seong-Kyu& Kim, Ha Neul& Lee, Ji-Hye& Lee, Ji-Hwan& Hwang, Deok-Sang…[et al.]. Gyejigachulbu-Tang Relieves Oxaliplatin-Induced Neuropathic Cold and Mechanical Hypersensitivity in Rats via the Suppression of Spinal Glial Activation. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1018471
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018471