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Antidepressant-Like Effects of Cordycepin in a Mice Model of Chronic Unpredictable Mild Stress
Joint Authors
Tianzhu, Zhang
Shihai, Yang
Juan, Du
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Cordycepin (3′-deoxyadenosine), a major bioactive component isolated from Cordyceps militaris, has multiple pharmacological activities.
This study is attempted to investigate whether cordycepin (COR) possesses beneficial effects on chronic unpredictable mild stress- (CUMS-) induced behavioral deficits (depression-like behaviors) and explore the possible mechanisms.
ICR mice were subjected to chronic unpredictable mild stress for 42 consecutive days.
Then, COR and fluoxetine (FLU, positive control drug) were administered for 21 consecutive days at the last three weeks of CUMS procedure.
The classical behavioral tests, open field test (OFT), sucrose preference test (SPT), tail suspension test (TST), and forced swimming test (FST), were applied to evaluate the antidepressant effects of COR.
Then the serotonin (5-HT) and noradrenaline (NE) concentrations in hippocampal were evaluated by HPLC; tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in hippocampal were evaluated, and the proteins of TNF-α, IL-6, NF-κBP65 5-HT 2A receptor (5-HT 2A R), and brain-derived neurotrophic factor (BDNF) in hippocampal were evaluated by Western blot.
Our results indicated that 6 weeks of CUMS exposure induced significant depression-like behavior, with low 5-HT and NE levels, high TNF-α and IL-6 in brain and high hippocampal TNF-α, IL-6, P-NF- κ BP65, and 5-HT 2A R levels, and low BDNF expression levels.
Whereas, chronic COR (20, 40 mg/kg) treatments reversed the behavioral deficiency induced by CUMS exposure, treatment with COR normalized the change of TNF-α, IL-6, 5-HT, and NE levels, which demonstrated that COR could partially restore CUMS-induced 5-HT receptor impairments and inflammation.
Besides, hippocampal BDNF expressions were also upregulated after COR treatments.
In conclusion, COR remarkably improved depression-like behavior in CUMS mice and its antidepressant activity is mediated, at least in part, by the upregulating BDNF and downregulating 5-HT 2A R levels and inflammation in hippocampus.
American Psychological Association (APA)
Tianzhu, Zhang& Shihai, Yang& Juan, Du. 2014. Antidepressant-Like Effects of Cordycepin in a Mice Model of Chronic Unpredictable Mild Stress. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1018476
Modern Language Association (MLA)
Tianzhu, Zhang…[et al.]. Antidepressant-Like Effects of Cordycepin in a Mice Model of Chronic Unpredictable Mild Stress. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1018476
American Medical Association (AMA)
Tianzhu, Zhang& Shihai, Yang& Juan, Du. Antidepressant-Like Effects of Cordycepin in a Mice Model of Chronic Unpredictable Mild Stress. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1018476
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018476