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Ethyl Acetate Extract from Celastrus aculeatus Merr. Suppresses Synovial Inflammation in Adjuvant Arthritis Rats through Apoptosis Induction of CD4+CD25+FOXP3+ T Cells
Joint Authors
Bai, Shu-tong
Chen, Pei-hong
Chen, Yu-yao
Lin, Xiao-chun
Liu, Jun-shan
Tong, Li
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Celastrus aculeatus Merr.
has been widely used in traditional Chinese medicine to treat rheumatoid arthritis (RA) in clinic.
However, the main active fraction of this plant is still unclear.
In this study, we attempted to evaluate the suppressive effect of ethyl acetate extract (EAE) from Celastrus aculeatus Merr.
on synovial inflammation in adjuvant arthritis (AA) rats induced by Mycobacterium tuberculosis H37Ra (Mtb) and to explore the underlying mechanisms.
SD rats immunized with heat-killed Mtb were fed with EAE and observed for erythema, swelling, and induration of each paw.
The pathologic changes in joint synovium were tested by hematoxylin-eosin staining.
Apoptosis induction of synoviocytes was tested immunohistochemically.
Apoptosis of peripheral lymphocytes and the level of regulatory T cells were analyzed by flow cytometry.
After treatment with EAE, the joint inflammation in rats with AA was alleviated.
Both apoptotic ratios of synoviocytes and peripheral lymphocytes and the ratio of CD4+CD25+FOXP3+ to CD4 regulatory T cells were significantly increased.
In summary, we first demonstrated that EAE of Celastrus aculeatus Merr.
can inhibit synovial inflammation in AA rats through apoptosis induction of CD4+CD25+FOXP3+ T cells.
Our study provides a rationale for the application of Celastrus aculeatus Merr.
to treat RA.
American Psychological Association (APA)
Bai, Shu-tong& Chen, Pei-hong& Chen, Yu-yao& Lin, Xiao-chun& Liu, Jun-shan& Tong, Li. 2014. Ethyl Acetate Extract from Celastrus aculeatus Merr. Suppresses Synovial Inflammation in Adjuvant Arthritis Rats through Apoptosis Induction of CD4+CD25+FOXP3+ T Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1018497
Modern Language Association (MLA)
Bai, Shu-tong…[et al.]. Ethyl Acetate Extract from Celastrus aculeatus Merr. Suppresses Synovial Inflammation in Adjuvant Arthritis Rats through Apoptosis Induction of CD4+CD25+FOXP3+ T Cells. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1018497
American Medical Association (AMA)
Bai, Shu-tong& Chen, Pei-hong& Chen, Yu-yao& Lin, Xiao-chun& Liu, Jun-shan& Tong, Li. Ethyl Acetate Extract from Celastrus aculeatus Merr. Suppresses Synovial Inflammation in Adjuvant Arthritis Rats through Apoptosis Induction of CD4+CD25+FOXP3+ T Cells. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1018497
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018497