Immunomodulatory and Antidiabetic Effects of a New Herbal Preparation (HemoHIM) on Streptozotocin-Induced Diabetic Mice
Joint Authors
Kim, Jong-Jin
Choi, Jina
Lee, Mi-Kyung
Kang, Kyung-Yun
Paik, Man-Jeong
Jo, Sung-Kee
Jung, Uhee
Park, Hae-Ran
Yee, Sung-Tae
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
HemoHIM (a new herbal preparation of three edible herbs: Angelica gigas Nakai, Cnidium officinale Makino, and Paeonia japonica Miyabe) was developed to protect immune, hematopoietic, and self-renewal tissues against radiation.
This study determined whether or not HemoHIM could alter hyperglycemia and the immune response in diabetic mice.
Both nondiabetic and diabetic mice were orally administered HemoHIM (100 mg/kg) once a day for 4 weeks.
Diabetes was induced by single injection of streptozotocin (STZ, 200 mg/kg, i.p.).
In diabetic mice, HemoHIM effectively improved hyperglycemia and glucose tolerance compared to the diabetic control group as well as elevated plasma insulin levels with preservation of insulin staining in pancreatic β-cells.
HemoHIM treatment restored thymus weight, white blood cells, lymphocyte numbers, and splenic lymphocyte populations (CD4+ T and CD8+ T), which were reduced in diabetic mice, as well as IFN-γ production in response to Con A stimulation.
These results indicate that HemoHIM may have potential as a glucose-lowering and immunomodulatory agent by enhancing the immune function of pancreatic β-cells in STZ-induced diabetic mice.
American Psychological Association (APA)
Kim, Jong-Jin& Choi, Jina& Lee, Mi-Kyung& Kang, Kyung-Yun& Paik, Man-Jeong& Jo, Sung-Kee…[et al.]. 2014. Immunomodulatory and Antidiabetic Effects of a New Herbal Preparation (HemoHIM) on Streptozotocin-Induced Diabetic Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1018503
Modern Language Association (MLA)
Kim, Jong-Jin…[et al.]. Immunomodulatory and Antidiabetic Effects of a New Herbal Preparation (HemoHIM) on Streptozotocin-Induced Diabetic Mice. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1018503
American Medical Association (AMA)
Kim, Jong-Jin& Choi, Jina& Lee, Mi-Kyung& Kang, Kyung-Yun& Paik, Man-Jeong& Jo, Sung-Kee…[et al.]. Immunomodulatory and Antidiabetic Effects of a New Herbal Preparation (HemoHIM) on Streptozotocin-Induced Diabetic Mice. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1018503
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018503