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Capilliposide Isolated from Lysimachia capillipes Hemsl. Induces ROS Generation, Cell Cycle Arrest, and Apoptosis in Human Nonsmall Cell Lung Cancer Cell Lines
Joint Authors
Fei, Zheng-hua
Wu, Kan
Chen, Yun-liang
Wang, Bing
Zhang, Shi-rong
Ma, Sheng-lin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-08
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Several data has reported that capilliposide, extracted from a traditional Chinese medicine, Lysimachia capillipes Hemsl.
(LC) could exhibit inhibitory effect on cell proliferation in various cancers.
The current study investigated the antitumor efficacy of Capilliposide and elucidated its potential molecular mechanism involved in vivo and vitro.
Our results indicated that LC capilliposide inhibited proliferation of lung cancer cells in a dose-dependent manner.
LC capilliposide induced cell cycle arrest at the S stage and enhanced apoptosis in NSCLC cells.
Treatment with LC capilliposide increased the intracellular level of ROS, which activated the mitochondrial apoptotic pathway.
Blockage of ROS by NAC highly reversed the effect of LC capilliposide on apoptosis.
Xenograft tumor growth was significantly lower in the LC-treated group compared with the untreated control group (P<0.05).
The results also show that LC treatment does not produce any overt signs of acute toxicity in vivo.
These findings demonstrate that LC capilliposide could exert an anti-tumor effect on NSCLC through mitochondrial-mediated apoptotic pathway and the activation of ROS is involved.
American Psychological Association (APA)
Fei, Zheng-hua& Wu, Kan& Chen, Yun-liang& Wang, Bing& Zhang, Shi-rong& Ma, Sheng-lin. 2014. Capilliposide Isolated from Lysimachia capillipes Hemsl. Induces ROS Generation, Cell Cycle Arrest, and Apoptosis in Human Nonsmall Cell Lung Cancer Cell Lines. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1018575
Modern Language Association (MLA)
Fei, Zheng-hua…[et al.]. Capilliposide Isolated from Lysimachia capillipes Hemsl. Induces ROS Generation, Cell Cycle Arrest, and Apoptosis in Human Nonsmall Cell Lung Cancer Cell Lines. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1018575
American Medical Association (AMA)
Fei, Zheng-hua& Wu, Kan& Chen, Yun-liang& Wang, Bing& Zhang, Shi-rong& Ma, Sheng-lin. Capilliposide Isolated from Lysimachia capillipes Hemsl. Induces ROS Generation, Cell Cycle Arrest, and Apoptosis in Human Nonsmall Cell Lung Cancer Cell Lines. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1018575
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018575