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Effects of an Aqueous Extract of Dangguijagyagsan on Serum Lipid Levels and Blood Flow Improvement in Ovariectomized Rats
Joint Authors
Ko, Byoung-Seob
Park, In Sil
Lee, Hye Won
Ryuk, Jin Ah
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Dangguijagyagsan (DJS), a traditional herbal prescription, has long been used to treat menopause-related symptoms.
We identified the cardioprotective effects of an aqueous extract of DJS using an ovariectomized (OVX) and ferric chloride- (FeCl-) induced carotid thrombosis rat model.
Female Sprague-Dawley (SD) rats were ovariectomized or Sham-operated (Sham-control).
The ovariectomized rats were divided into three groups: OVX with saline (OVX-control), aspirin 30 mg/kg/day (OVX-ASA), and DJS 100 mg/kg/day (OVX-DJS).
The treatments were administered for 5 weeks.
Then, blood samples were collected to analyze the serum lipid levels and platelet aggregation.
The topical application of 40% FeCl3 induced intravascular thrombosis, which was used to test thrombotic occlusion and for histological examination.
Body weight and the levels of total cholesterol (TC), triglyceride (TG), and LDL-cholesterol (LDL-C) increased in the OVX rats.
These effects were reduced by ASA and DJS treatment.
In addition, ASA and DJS treatment significantly inhibited platelet aggregation.
These treatments also increased time to occlusion and decreased both thrombus size and the presence of collagen fibers in surrounding vessel walls compared with the Sham-control and OVX-control groups.
These results suggest that DJS has beneficial effects in terms of preventing cardiovascular disease in menopausal woman because it can reduce the serum lipid levels and improve blood flow by inhibiting platelet aggregation and thrombus formation.
American Psychological Association (APA)
Park, In Sil& Lee, Hye Won& Ryuk, Jin Ah& Ko, Byoung-Seob. 2014. Effects of an Aqueous Extract of Dangguijagyagsan on Serum Lipid Levels and Blood Flow Improvement in Ovariectomized Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1018576
Modern Language Association (MLA)
Park, In Sil…[et al.]. Effects of an Aqueous Extract of Dangguijagyagsan on Serum Lipid Levels and Blood Flow Improvement in Ovariectomized Rats. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1018576
American Medical Association (AMA)
Park, In Sil& Lee, Hye Won& Ryuk, Jin Ah& Ko, Byoung-Seob. Effects of an Aqueous Extract of Dangguijagyagsan on Serum Lipid Levels and Blood Flow Improvement in Ovariectomized Rats. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1018576
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018576