Ginseng Total Saponins Reverse Corticosterone-Induced Changes in Depression-Like Behavior and Hippocampal Plasticity-Related Proteins by Interfering with GSK-3 β-CREB Signaling Pathway
Joint Authors
Chen, Lin
Dai, Jianguo
Wang, Zhongli
Zhang, Huiyu
Huang, Yufang
Zhao, Yunan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
This study aimed to explore the antidepressant mechanisms of ginseng total saponins (GTS) in the corticosterone-induced mouse depression model.
In Experiment 1, GTS (50, 25, and 12.5 mg kg−1 d−1, intragastrically) were given for 3 weeks.
In Experiment 2, the same doses of GTS were administrated after each corticosterone (20 mg kg−1 d−1, subcutaneously) injection for 22 days.
In both experiments, mice underwent a forced swimming test and a tail suspension test on day 20 and day 21, respectively, and were sacrificed on day 22.
Results of Experiment 1 revealed that GTS (50 and 25 mg kg−1 d−1) exhibited antidepressant activity and not statistically altered hippocampal protein levels of brain-derived neurotrophic factor (BDNF) and neurofilament light chain (NF-L).
Results of Experiment 2 showed that GTS (50 and 25 mg kg−1 d−1) ameliorated depression-like behavior without normalizing hypercortisolism.
The GTS treatments reversed the corticosterone-induced changes in mRNA levels of BDNF and NF-L, and protein levels of BDNF NF-L, phosphor-cAMP response element-binding protein (Ser133), and phosphor-glycogen synthase kinase-3β (Ser9) in the hippocampus.
These findings imply that the effect of GTS on corticosterone-induced depression-like behavior may be mediated partly through interfering with hippocampal GSK-3β-CREB signaling pathway and reversing decrease of some plasticity-related proteins.
American Psychological Association (APA)
Chen, Lin& Dai, Jianguo& Wang, Zhongli& Zhang, Huiyu& Huang, Yufang& Zhao, Yunan. 2014. Ginseng Total Saponins Reverse Corticosterone-Induced Changes in Depression-Like Behavior and Hippocampal Plasticity-Related Proteins by Interfering with GSK-3 β-CREB Signaling Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1018586
Modern Language Association (MLA)
Chen, Lin…[et al.]. Ginseng Total Saponins Reverse Corticosterone-Induced Changes in Depression-Like Behavior and Hippocampal Plasticity-Related Proteins by Interfering with GSK-3 β-CREB Signaling Pathway. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1018586
American Medical Association (AMA)
Chen, Lin& Dai, Jianguo& Wang, Zhongli& Zhang, Huiyu& Huang, Yufang& Zhao, Yunan. Ginseng Total Saponins Reverse Corticosterone-Induced Changes in Depression-Like Behavior and Hippocampal Plasticity-Related Proteins by Interfering with GSK-3 β-CREB Signaling Pathway. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1018586
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1018586